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Partial Splenic Embolization for the Treatment of Hereditary Spherocytosis

¹ All authors: Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670 Japan.

View larger version (111K): [in a new window]   Fig. 1. —33-year-old woman with hereditary spherocytosis who responded to partial splenic embolization. CT scan (window level, 30 H; width, 250 H) 5 days after embolization shows spleen 96% infarcted and line of demarcation between infarcted (arrows) and normal regions.

View larger version (16K): [in a new window]   Fig. 2A. —Changes in blood values after partial splenic embolization. Black square, black triangle, circle, white triangle, and white square correspond to patient numbers 1, 2, 3, 4, and 5, respectively. Graph shows changes in hemoglobin levels. In all patients, hemoglobin levels were maintained at 12 g/dL or more during follow-up periods.

View larger version (17K): [in a new window]   Fig. 2B. —Changes in blood values after partial splenic embolization. Black square, black triangle, circle, white triangle, and white square correspond to patient numbers 1, 2, 3, 4, and 5, respectively. Graph shows changes in hematocrit values. In all patients, hematocrit values were maintained at 33% or more during follow-up periods.

View larger version (18K): [in a new window]   Fig. 2C. —Changes in blood values after partial splenic embolization. Black square, black triangle, circle, white triangle, and white square correspond to patient numbers 1, 2, 3, 4, and 5, respectively. Graph shows changes in reticulocyte counts. In four of five patients, reticulocyte counts were maintained at less than 55 x 109/L during follow-up periods. In another patient, reticulocyte count partially relapsed at 12 months after embolization and stabilized at approximately 100 x 109/L for 7 years.

View larger version (17K): [in a new window]   Fig. 2D. —Changes in blood values after partial splenic embolization. Black square, black triangle, circle, white triangle, and white square correspond to patient numbers 1, 2, 3, 4, and 5, respectively. Graph shows changes in total serum bilirubin levels. Levels were maintained at less than 60 µmol/L during follow-up periods in all patients.

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