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Effects of IV Pentobarbital With and Without Fentanyl on End-Tidal Carbon Dioxide Levels During Deep Sedation of Pediatric Patients Undergoing MRI

Linda Connor1, Patricia E. Burrows1, David Zurakowski2, Kathleen Bucci1, Denise A. Gagnon1 and Keira P. Mason1,3

1 Department of Radiology, Children's Hospital, 300 Longwood Ave., Harvard Medical School, Boston, MA 02115.
2 Departments of Biostatistics and Orthopaedic Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115.
3 Department of Anesthesia, Children's Hospital, Harvard Medical School, Boston, MA 02115.



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  		Fig. 1. —Graph shows comparison of end-tidal carbon dioxide during deep sedation for patients who received IV pentobarbital alone (, n = 140) compared with those who received IV pentobarbital plus IV fentanyl ({Delta}, n = 25). Curves illustrate significantly faster rate of increase in end-tidal carbon dioxide for group who had fentanyl added, as depicted by steeper slope (p = 0.004, F test).

 


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  		Fig. 2. —Graph illustrates end-tidal carbon dioxide during deep sedation in patients who received pentobarbital alone (n = 140) and compares those who received 3–5 mg/kg (, n = 103) with those who received more than 5 mg/kg ({Delta}, n = 37) of IV pentobarbital. Parallel curves illustrate no significant difference in rate of increase in end-tidal carbon dioxide between two groups (p = 0.97, F test). Patients who received more than 5 mg/kg of IV pentobarbital showed slightly higher end-tidal carbon dioxide across sedation period.

 

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