CT Findings of Surgically Resected Large Cell Neuroendocrine Carcinoma of the Lung in 38 Patients
Yasuji Oshiro1,
Masahiko Kusumoto2,
Yoshihiro Matsuno3,
Hisao Asamura4,
Ryousuke Tsuchiya4,
Hiroshi Terasaki5,
Hidefumi Takei3,
Arafumi Maeshima6,
Sadayuki Murayama1 and
Noriyuki Moriyama2
1 Department of Radiology, University of Ryukyus School of Medicine, 207 Uehara,
Nishihara-cho, Okinawa Prefecture 903-0215, Japan.
2 Diagnostic Radiology Division, National Cancer Center Hospital, 1-1 Tsukiji
5-chome, Chuou-ku, Tokyo 104-0045, Japan.
3 Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 104-0045,
Japan.
4 Thoracic Surgery Division, National Cancer Center Hospital, Tokyo 104-0045,
Japan.
5 Department of Radiology, Kurume University School of Medicine, 67-Asahimachi,
Kurume 830-0011, Japan.
6 Pathology Division, National Cancer Center Research Institute, 1-1 Tsukiji
5-chome, Chuou-ku, Tokyo 104-0045, Japan.

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Fig. 1. Thin-section (2-mm collimation) CT scan obtained with lung
window setting in right lower lobe of 77-year-old man with large cell
neuroendocrine carcinoma shows well-defined lobulated nodule.
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Fig. 2A. Large cell neuroendocrine carcinoma in 71-year-old-man.
Contrast-enhanced conventional 10-mm-thick CT scan obtained in right upper
lobe shows round nodule with mild homogeneous enhancement.
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Fig. 2B. Large cell neuroendocrine carcinoma in 71-year-old-man.
Thin-section (2-mm collimation) CT scan obtained with lung window setting
shows ill-defined spiculated nodule. Coarse spiculation (arrows) is
evident around periphery of tumor with extension to pleural surface and into
emphysematous lung.
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Fig. 3A. Large cell neuroendocrine carcinoma in 82-year-old man.
Contrast-enhanced conventional 10-mm-thick CT scan obtained in left upper lobe
shows lobulated nodule (arrow) with mild homogeneous enhancement.
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Fig. 3B. Large cell neuroendocrine carcinoma in 82-year-old man.
Thin-section (2-mm-collimation) CT scan obtained with lung window setting
shows ill-defined spiculated nodule (straight arrows) with pleural
indentation (curved arrow).
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Fig. 3C. Large cell neuroendocrine carcinoma in 82-year-old man.
Photomicrograph of histopathologic specimen exhibits spiculated margins due to
vascular invasion (arrow) and irregularly protuberant tumor nest
(arrowhead). (H and E, x3)
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Copyright © 2004 by the American Roentgen Ray Society.