Prognostic Significance of MRI Findings in Patients with MyxoidRound Cell Liposarcoma
Ukihide Tateishi1,
Tadashi Hasegawa2,
Yasuo Beppu3,
Akira Kawai3,
Mitsuo Satake1 and
Noriyuki Moriyama1
1 Division of Diagnostic Radiology, National Cancer Center Hospital and Research
Institute, Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.
2 Division of Pathology, National Cancer Center Hospital and Research Institute,
Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.
3 Division of Orthopedics, National Cancer Center Hospital and Research
Institute, Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.

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Fig. 1A. 38-year-old woman with low-grade myxoidround cell
liposarcoma in left thigh. T1-weighted spin-echo MR image (TR/TE, 720/20)
shows tumor has regular contours with small amount of fat signal in periphery
(arrowhead).
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Fig. 1B. 38-year-old woman with low-grade myxoidround cell
liposarcoma in left thigh. Contrast-enhanced T1-weighted spin-echo MR image
(720/20) shows diffuse enhancement of tumor.
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Fig. 2A. 62-year-old man with low-grade myxoidround cell
liposarcoma in left buttock. Axial T2-weighted fast spin-echo MR image (TR/TE,
3,500/100) shows septate appearance of lesion. Linear structures of low
intensity contained thick septa (arrow) and thin septa
(arrowheads).
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Fig. 2B. 62-year-old man with low-grade myxoidround cell
liposarcoma in left buttock. Axial fat-saturated contrast-enhanced T1-weighted
spin-echo MR image (720/20) shows tumor of high intensity with slight
enhancement of septa.
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Fig. 2C. 62-year-old man with low-grade myxoidround cell
liposarcoma in left buttock. Photomicrograph of specimen shows paucicellular
myxoid liposarcoma with less than 25% round cell components has dispersed
small round or short spindled cells and multivacuolated lipoblasts within
abundant myxoid matrix and plexiform vascular network. (H and E,
x200)
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Fig. 3A. 28-year-old man with intermediate-grade myxoidround
cell liposarcoma in left thigh. Axial T1-weighted spin-echo MR image (TR/TE,
650/12) shows high-intensity signal pattern (arrowheads) in periphery
of tumor.
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Fig. 3B. 28-year-old man with intermediate-grade myxoidround
cell liposarcoma in left thigh. Fat-suppressed contrast-enhanced T1-weighted
spin-echo MR image (650/12) shows pseudocapsular enhancement (arrows)
and globular and nodular enhancement (arrowheads).
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Fig. 3C. 28-year-old man with intermediate-grade myxoidround
cell liposarcoma in left thigh. Photomicrograph of specimen shows cellular
myxoid liposarcoma with round cell components composed of solid sheets of
round cells with large and coarse chromatin and little intervening myxoid
stroma. (H and E, x200)
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Fig. 4A. 69-year-old man with high-grade myxoidround cell
liposarcoma in left thigh. Sagittal contrast-enhanced T1-weighted spin-echo MR
image (TR/TE, 600/15) shows globular and nodular enhancement (arrows)
and pronounced enhancement (arrowheads) predominantly at tumor
periphery.
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Fig. 4B. 69-year-old man with high-grade myxoidround cell
liposarcoma in left thigh. Photograph of macroscopic specimen of same tumor as
in A shows heterogeneous tumor components (arrowheads).
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Fig. 4C. 69-year-old man with high-grade myxoidround cell
liposarcoma in left thigh. Photomicrograph shows that specimen is composed of
solid sheets of uniform round cells with large and coarse chromatin. (H and E,
x200)
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Fig. 5. Graph shows Kaplan-Meier survival curve according to presence
(solid line) or absence (dashed line) of pronounced
enhancement on contrast-enhanced MR images for 36 patients with
myxoidround cell liposarcomas.
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Copyright © 2004 by the American Roentgen Ray Society.