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Prognostic Significance of MRI Findings in Patients with Myxoid–Round Cell Liposarcoma

Ukihide Tateishi1, Tadashi Hasegawa2, Yasuo Beppu3, Akira Kawai3, Mitsuo Satake1 and Noriyuki Moriyama1

1 Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.
2 Division of Pathology, National Cancer Center Hospital and Research Institute, Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.
3 Division of Orthopedics, National Cancer Center Hospital and Research Institute, Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.



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Fig. 1A. 38-year-old woman with low-grade myxoid–round cell liposarcoma in left thigh. T1-weighted spin-echo MR image (TR/TE, 720/20) shows tumor has regular contours with small amount of fat signal in periphery (arrowhead).

 


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Fig. 1B. 38-year-old woman with low-grade myxoid–round cell liposarcoma in left thigh. Contrast-enhanced T1-weighted spin-echo MR image (720/20) shows diffuse enhancement of tumor.

 


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Fig. 2A. 62-year-old man with low-grade myxoid–round cell liposarcoma in left buttock. Axial T2-weighted fast spin-echo MR image (TR/TE, 3,500/100) shows septate appearance of lesion. Linear structures of low intensity contained thick septa (arrow) and thin septa (arrowheads).

 


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Fig. 2B. 62-year-old man with low-grade myxoid–round cell liposarcoma in left buttock. Axial fat-saturated contrast-enhanced T1-weighted spin-echo MR image (720/20) shows tumor of high intensity with slight enhancement of septa.

 


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Fig. 2C. 62-year-old man with low-grade myxoid–round cell liposarcoma in left buttock. Photomicrograph of specimen shows paucicellular myxoid liposarcoma with less than 25% round cell components has dispersed small round or short spindled cells and multivacuolated lipoblasts within abundant myxoid matrix and plexiform vascular network. (H and E, x200)

 


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Fig. 3A. 28-year-old man with intermediate-grade myxoid–round cell liposarcoma in left thigh. Axial T1-weighted spin-echo MR image (TR/TE, 650/12) shows high-intensity signal pattern (arrowheads) in periphery of tumor.

 


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Fig. 3B. 28-year-old man with intermediate-grade myxoid–round cell liposarcoma in left thigh. Fat-suppressed contrast-enhanced T1-weighted spin-echo MR image (650/12) shows pseudocapsular enhancement (arrows) and globular and nodular enhancement (arrowheads).

 


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Fig. 3C. 28-year-old man with intermediate-grade myxoid–round cell liposarcoma in left thigh. Photomicrograph of specimen shows cellular myxoid liposarcoma with round cell components composed of solid sheets of round cells with large and coarse chromatin and little intervening myxoid stroma. (H and E, x200)

 


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Fig. 4A. 69-year-old man with high-grade myxoid–round cell liposarcoma in left thigh. Sagittal contrast-enhanced T1-weighted spin-echo MR image (TR/TE, 600/15) shows globular and nodular enhancement (arrows) and pronounced enhancement (arrowheads) predominantly at tumor periphery.

 


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Fig. 4B. 69-year-old man with high-grade myxoid–round cell liposarcoma in left thigh. Photograph of macroscopic specimen of same tumor as in A shows heterogeneous tumor components (arrowheads).

 


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Fig. 4C. 69-year-old man with high-grade myxoid–round cell liposarcoma in left thigh. Photomicrograph shows that specimen is composed of solid sheets of uniform round cells with large and coarse chromatin. (H and E, x200)

 


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Fig. 5. Graph shows Kaplan-Meier survival curve according to presence (solid line) or absence (dashed line) of pronounced enhancement on contrast-enhanced MR images for 36 patients with myxoid–round cell liposarcomas.

 

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