Correlating MRI and Histologic Tumor Thickness in the Assessment of Oral Tongue Cancer
Paul Lam1,
Kai Ming Au-Yeung2,
Pui Wai Cheng2,
William Ignace Wei1,
Anthony Po-Wing Yuen1,
Nigel Trendell-Smith3,
Jimmy H. C. Li2 and
Raymond Li2
1 Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery,
The University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam
Rd., Hong Kong.
2 Department of Radiology, The University of Hong Kong Medical Centre, Queen
Mary Hospital, Hong Kong.
3 Department of Pathology, The University of Hong Kong Medical Centre, Queen
Mary Hospital, Hong Kong.
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Fig. 1. —Photograph of histologic slide obtained in 43-year-old man
with oral tongue cancer. We calculated tumor thickness by adding measurements
of largest exophytic (A) and largest endophytic (B) parts of tumor.
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Fig. 2A. —68-year-old man with biopsy-proven oral tongue cancer and
histologically determined tumor thickness of 2 mm. Coronal contrast-enhanced
T1-weighted spin-echo image shows horizontal line (arrowhead)
connecting two tumor–mucosa junctions as reference line. Vertical line
(arrow) drawn perpendicular to it represents radiologically
determined tumor thickness of 3 mm.
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Fig. 3A. —43-year-old man with biopsy-proven oral tongue cancer and
histologically determined tumor thickness of 9 mm. Coronal contrast-enhanced
T1-weighted spin-echo image shows horizontal line (arrowhead)
connecting two tumor–mucosa junctions as reference line. Vertical lines
(arrows) drawn perpendicular to it (including exophytic and
endophytic parts of tumor) represent radiologically determined tumor thickness
of 8 mm.
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Fig. 4A. —84-year-old man with biopsy-proven oral tongue cancer and
histologically determined tumor thickness of 18 mm. Coronal contrast-enhanced
T1-weighted spin-echo image shows horizontal line (arrowhead)
connecting two tumor–mucosa junctions as reference line. Vertical lines
(arrows) drawn perpendicular to it represent radiologically
determined tumor thickness of 23 mm.
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Fig. 2B. —68-year-old man with biopsy-proven oral tongue cancer and
histologically determined tumor thickness of 2 mm. Coronal T2-weighted
spin-echo image obtained at same level as A shows horizontal reference
line (arrowhead) and perpendicular vertical line (arrow)
representing radiologically determined tumor thickness of 2 mm.
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Fig. 3B. —43-year-old man with biopsy-proven oral tongue cancer and
histologically determined tumor thickness of 9 mm. Coronal T2-weighted
spin-echo image obtained at same level as A shows horizontal reference
line (arrowhead) and perpendicular vertical lines (arrows)
representing radiologically determined tumor thickness of 10 mm.
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Fig. 4B. —84-year-old man with biopsy-proven oral tongue cancer and
histologically determined tumor thickness of 18 mm. Coronal T2-weighted
spin-echo MR image obtained at same level as A shows horizontal
reference line (arrowhead) and perpendicular vertical lines
(arrows) representing radiologically determined tumor thickness of 25
mm.
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Fig. 5. —Scatterplot shows mean tumor thickness as determined from
histologic specimens compared with tumor thickness as determined from
contrast-enhanced T1-weighted spin-echo images. R = 0.938, Y
= –0.336 + 0.957 X.
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Fig. 6. —Scatterplot shows mean tumor thickness as determined from
histologic specimens compared with mean tumor thickness as determined from
T2-weighted spin-echo images. R = 0.941, Y = 0.203 + 0.803
X.
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Copyright © 2004 by the American Roentgen Ray Society.
