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Routine Use of Gradient-Echo MRI to Screen for Cerebral Amyloid Angiopathy in Elderly Patients

D. A. Walker1, D. F. Broderick1, A. L. Kotsenas1 and F. A. Rubino2

1 Department of Radiology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224-1865.
2 Department of Neurology, Mayo Clinic, Jacksonville, FL 32224-1865.



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  		Fig. 1A. —71-year-old woman with biopsy-proven cerebral amyloid angiopathy. Gradient-refocused echo images show multiple small (< 5 mm) round foci of decreased signal intensity that are conspicuous.

 


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  		Fig. 1B. —71-year-old woman with biopsy-proven cerebral amyloid angiopathy. T2-weighted fast spin-echo images show same small hypointensities as in A to be barely discernible.

 


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  		Fig. 1C. —71-year-old woman with biopsy-proven cerebral amyloid angiopathy. Diffusion-weighted images also show same hypointensities as in A to be barely discernible, if at all.

 


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  		Fig. 2. —Bar graph shows percentage of total patients evaluated as positive or negative for cerebral microbleeding (CMB) in lobar–cortical pattern typical of cerebral amyloid angiopathy.

 


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  		Fig. 3. —Bar graph shows percentage of patients positive for cerebral microbleeding in which cerebral amyloid angiopathy (CAA) was clinically unsuspected.

 


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  		Fig. 4. —Bar graph shows percentage of patients in both patient groups (positive or negative for cerebral microbleeding [CMB]) who were taking warfarin sodium (black bar) or aspirin (white bar).

 

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