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Histopathologic Evaluation of Tissue Extracted on the Radiofrequency Probe After Ablation of Liver Tumors: Preliminary Findings

Constantinos T. Sofocleous1,2, Kenneth M. Klein3, Basil Hubbi4, Karen T. Brown2, Stanley H. Weiss5, George Kannarkat4, Clay R. Hinrichs1, Daniel Contractor1, Philip Bahramipour1, Allison Barone1 and Stephen R. Baker1

1 Department of Radiology, University of Medicine and Dentistry of New Jersey–Newark, Newark, NJ.
2 Present address: Department of Interventional Radiology, Memorial Sloan-Kettering Cancer Center, Weil Medical College, Cornell University, 1275 York Ave., New York, NY 10021.
3 Department of Pathology, University of Medicine and Dentistry of New Jersey–Newark, Newark, NJ.
4 New Jersey Medical School, University of Medicine and Dentistry of New Jersey–Newark, Newark, NJ.
5 Department of Epidemiology and Preventive Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey–Newark, Newark, NJ.



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  		Fig. 1A. —Tissue fragments extracted by radiofrequency ablation probe. Photograph shows needle probe after radiofrequency ablation and removal from patient's body, with fragments of extracted tissue on reexpanded electrodes.

 


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  		Fig. 1B. —Tissue fragments extracted by radiofrequency ablation probe. Photograph shows fragment collected from probe, measured with ruler in centimeters.

 


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  		Fig. 2A. —Histopathologic findings after radiofrequency ablation. Photomicrograph shows coagulation necrosis immediately after radiofrequency ablation of hepatocellular carcinoma (Table 1, patient 3).

 


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  		Fig. 2B. —Histopathologic findings after radiofrequency ablation. Photomicrograph shows possibly nonviable tissue. Coagulation necrosis is interrupted by nest of tumor (hepatocellular carcinoma) cells, which are smudged and somewhat distorted. Cytoplasm and nuclei of tumor cells are not as clearly seen (Table 1, patient 14).

 


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  		Fig. 2C. —Histopathologic findings after radiofrequency ablation. Photomicrograph shows possibly viable tissue. Note nest of malignant cells (hepatocellular carcinoma) (Table 1, patient 6).

 

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