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Placental Transmogrification of the Lung: CT–Pathologic Correlation of a Rare Pulmonary Nodule

G. R. Ferretti1, M. Kocier1, D. Moro-Sibilot2, P. Y. Brichon3 and S. Lantuejoul4

1 Service de Radiologie et Imagerie Médicale, CHU Grenoble, BP 217, Grenoble 38043, CEDEX 9, France.
2 Département de Médecine Aiguë Spécialisée, CHU Grenoble, France.
3 Service de Chirurgie Thoracique, CHU Grenoble, France.
4 Service de Pathologie Cellulaire, CHU Grenoble, France.



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  		Fig. 1A. —40-year-old asymptomatic man with well-defined subpleural nodule in left lower lobe. High-resolution CT scan obtained using lung window settings shows upper part of nodule is limited by thin wall (arrow) and contains air.

 


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  		Fig. 1B. —40-year-old asymptomatic man with well-defined subpleural nodule in left lower lobe. High-resolution CT scan obtained using mediastinal window settings shows that central part of nodule combines air and soft-tissue densities.

 


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  		Fig. 1C. —40-year-old asymptomatic man with well-defined subpleural nodule in left lower lobe. High-resolution CT scan obtained using lung window settings shows that central part of nodule contains soft-tissue and fat-tissue (–60 H) attenuating components.

 


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  		Fig. 1D. —40-year-old asymptomatic man with well-defined subpleural nodule in left lower lobe. Histomicrograph shows microscopic features of placental transmogrification. Lesion abuts visceral pleura and is composed of villuslike structures admixed with remnants of alveolar walls, with core of structures being filled by mature adipose tissue. (H and E, and saffron, x100)

 

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