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MRI for Detection of Hepatocellular Carcinoma: Comparison of Mangafodipir Trisodium and Gadopentetate Dimeglumine Contrast Agents

Ji Hyun Youk1, Jeong Min Lee2 and Chong Soo Kim1

1 Department of Diagnostic Radiology, Chonbuk National University Hospital, Conju, South Korea.
2 Department of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, 28, Yongondong, Chongno-gu, Seoul 110-744, South Korea.



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  		Fig. 1. —Results of receiver operator characteristic (ROC) analysis. Graph of mean area under ROC curves (Az) with pooled data of two observers indicates diagnostic accuracy of gadopentetate dimeglumine–mangafodipir trisodium (Mn-DPDP) set ({blacktriangleup}), gadopentetate dimeglumine set ({diamondsuit}), and Mn-DPDP set ({blacksquare}).

 


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  		Fig. 2A. —MR images of 52-year-old man with arterioportal shunt. Mangafodipir trisodium–enhanced T1-weighted 3D fast low-angle shot (FLASH) image with fat saturation shows no evidence of malignant hepatic nodule or mass.

 


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  		Fig. 2B. —MR images of 52-year-old man with arterioportal shunt. On gadopentetate dimeglumine–enhanced T1-weighted 3D FLASH images with fat saturation, subcapsular enhancement (arrow) is shown in arterial (B) and portal (C) phases. Area of enhancement is not a true lesion but is an arterioportal shunt combined with cirrhosis.

 


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  		Fig. 2C. —MR images of 52-year-old man with arterioportal shunt. On gadopentetate dimeglumine–enhanced T1-weighted 3D FLASH images with fat saturation, subcapsular enhancement (arrow) is shown in arterial (B) and portal (C) phases. Area of enhancement is not a true lesion but is an arterioportal shunt combined with cirrhosis.

 


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  		Fig. 3A. —76-year-old man with hepatocellular carcinoma. On gadopentetate dimeglumine–enhanced arterial phase T1-weighted 3D fast low-angle shot (FLASH) image with fat saturation, well-enhancing lesion (arrow) is seen in liver segment VI.

 


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  		Fig. 3B. —76-year-old man with hepatocellular carcinoma. In portal phase, contrast medium is washed out in lesion so is not depicted.

 


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  		Fig. 3C. —76-year-old man with hepatocellular carcinoma. On mangafodipir trisodium–-enhanced T1-weighted 3D FLASH image with fat saturation, lesion is isointense to liver and is therefore not detected.

 

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