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Computer-Aided Detection in Diagnostic Mammography: Detection of Clinically Unsuspected Cancers

Sherry A. Butler1, Richard J. Gabbay2, Deborah A. Kass2, Daniel E. Siedler2, Kathryn F. O'Shaughnessy3 and Ronald A. Castellino3

1 Department of Radiology, Kaiser Permanente, 2238 Geary Blvd., San Francisco, CA 94115.
2 Department of Radiology, Kaiser Permanente, 1150 Veterans Blvd., Redwood City, CA 94063.
3 R2 Technology, 1195 W Fremont Ave., Sunnyvale, CA 94087.



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  		Fig. 1. —Diagram shows how study cases were identified from initial set of consecutive diagnostic mammograms.

 


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  		Fig. 2A. —49-year-old woman who presented with periodic bilateral breast pain. Craniocaudal (A) and mediolateral oblique (B) mammograms of right breast are shown. Radiologist detected 2-cm mass (arrow, A and B) in right breast (digital magnification: C is magnification of A, and D is magnification of B), proven at biopsy to be invasive ductal carcinoma. Mass was not retrospectively marked by computer-aided detection system.

 


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  		Fig. 2B. —49-year-old woman who presented with periodic bilateral breast pain. Craniocaudal (A) and mediolateral oblique (B) mammograms of right breast are shown. Radiologist detected 2-cm mass (arrow, A and B) in right breast (digital magnification: C is magnification of A, and D is magnification of B), proven at biopsy to be invasive ductal carcinoma. Mass was not retrospectively marked by computer-aided detection system.

 


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  		Fig. 2C. —49-year-old woman who presented with periodic bilateral breast pain. Craniocaudal (A) and mediolateral oblique (B) mammograms of right breast are shown. Radiologist detected 2-cm mass (arrow, A and B) in right breast (digital magnification: C is magnification of A, and D is magnification of B), proven at biopsy to be invasive ductal carcinoma. Mass was not retrospectively marked by computer-aided detection system.

 


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  		Fig. 2D. —49-year-old woman who presented with periodic bilateral breast pain. Craniocaudal (A) and mediolateral oblique (B) mammograms of right breast are shown. Radiologist detected 2-cm mass (arrow, A and B) in right breast (digital magnification: C is magnification of A, and D is magnification of B), proven at biopsy to be invasive ductal carcinoma. Mass was not retrospectively marked by computer-aided detection system.

 


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  		Fig. 3A. —58-year-old woman who presented with "pulling" on left inner breast, diagnosed with bilateral invasive ductal carcinoma after biopsy. Craniocaudal (A) and mediolateral oblique (B) mammograms are shown. Cancer in left breast at point of clinical finding is apparent. A second cancer (arrow, A and B) was detected in right breast (digital magnification: C is magnification of A, and D is magnification of B). Cancers in both left and right breasts were marked by computer-aided detection system.

 


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  		Fig. 3B. —58-year-old woman who presented with "pulling" on left inner breast, diagnosed with bilateral invasive ductal carcinoma after biopsy. Craniocaudal (A) and mediolateral oblique (B) mammograms are shown. Cancer in left breast at point of clinical finding is apparent. A second cancer (arrow, A and B) was detected in right breast (digital magnification: C is magnification of A, and D is magnification of B). Cancers in both left and right breasts were marked by computer-aided detection system.

 


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  		Fig. 3C. —58-year-old woman who presented with "pulling" on left inner breast, diagnosed with bilateral invasive ductal carcinoma after biopsy. Craniocaudal (A) and mediolateral oblique (B) mammograms are shown. Cancer in left breast at point of clinical finding is apparent. A second cancer (arrow, A and B) was detected in right breast (digital magnification: C is magnification of A, and D is magnification of B). Cancers in both left and right breasts were marked by computer-aided detection system.

 


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  		Fig. 3D. —58-year-old woman who presented with "pulling" on left inner breast, diagnosed with bilateral invasive ductal carcinoma after biopsy. Craniocaudal (A) and mediolateral oblique (B) mammograms are shown. Cancer in left breast at point of clinical finding is apparent. A second cancer (arrow, A and B) was detected in right breast (digital magnification: C is magnification of A, and D is magnification of B). Cancers in both left and right breasts were marked by computer-aided detection system.

 

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