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Giant Cell Interstitial Pneumonia: High-Resolution CT and Pathologic Findings in Four Adult Patients

Jin Wook Choi1, Kyung Soo Lee1, Man Pyo Chung2, Joungho Han3, Myung Jin Chung1 and Jai Soung Park4

1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710, Korea.
2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
3 Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
4 Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Kyungki-Do 420-853, Korea.



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  		Fig. 1A. —Giant cell interstitial pneumonia in 47-year-old man. Chest radiograph shows patchy ground-glass opacities and some reticular densities in both lungs.

 


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  		Fig. 1B. —Giant cell interstitial pneumonia in 47-year-old man. High-resolution (1.0-mm collimation) CT scans obtained with lung window settings at levels of inferior pulmonary vein (B) and liver dome (C) show patchy ground-glass opacities containing irregular linear opacities in both lungs. Nodule (arrow, C) is calcified granuloma.

 


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  		Fig. 1C. —Giant cell interstitial pneumonia in 47-year-old man. High-resolution (1.0-mm collimation) CT scans obtained with lung window settings at levels of inferior pulmonary vein (B) and liver dome (C) show patchy ground-glass opacities containing irregular linear opacities in both lungs. Nodule (arrow, C) is calcified granuloma.

 


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  		Fig. 1D. —Giant cell interstitial pneumonia in 47-year-old man. Low-magnification photomicrograph of histopathologic speciman shows interstitial thickening with inflammatory cell infiltration. Also note some prominent lymphoid follicles (arrows). (H and E, x12)

 


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  		Fig. 1E. —Giant cell interstitial pneumonia in 47-year-old man. High-magnification photomicrograph of histopathologic specimen shows macrophages and multinucleated giant cells (arrows) in alveolar spaces. (H and E, x100)

 


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  		Fig. 2A. —Giant cell interstitial pneumonia in 52-year-old man. Chest radiograph shows bilateral reticular densities in lower lung zones.

 


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  		Fig. 2B. —Giant cell interstitial pneumonia in 52-year-old man. High-resolution (1.0-mm collimation) CT scans obtained with lung window settings at levels of suprahepatic inferior vena cava (B) and liver dome (C) show subpleural ground-glass opacities, irregular linear opacities, and honeycombing in both lungs with lower lung zone predominance.

 


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  		Fig. 2C. —Giant cell interstitial pneumonia in 52-year-old man. High-resolution (1.0-mm collimation) CT scans obtained with lung window settings at levels of suprahepatic inferior vena cava (B) and liver dome (C) show subpleural ground-glass opacities, irregular linear opacities, and honeycombing in both lungs with lower lung zone predominance.

 

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