Radiofrequency Ablation of Thoracic Lesions: Part 1, Experiments in the Normal Porcine Thorax

Radiofrequency Ablation of Thoracic Lesions: Part 1, Experiments in the Normal Porcine Thorax

Paul R. Morrison¹, Eric vanSonnenberg¹^,2, Sridhar Shankar¹^,2^,3, John Godleski⁴, Stuart G. Silverman¹^,2, Kemal Tuncali¹^,2, Michael T. Jaklitsch⁵ and Ferenc A. Jolesz¹

¹ Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115.
² Department of Radiology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, MA 02115.
³ Present address: Department of Radiology, University of Massachusetts Medical Center, Worcester, MA.
⁴ Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
⁵ Department of Surgery, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA 02115.

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Fig. 1A. —Array-style radiofrequency electrode (3.5-cm diameter). Photograph shows deployed electrode. Inset shows electrode in its undeployed state.

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Fig. 1B. —Array-style radiofrequency electrode (3.5-cm diameter). Fluoroscopic image shows appearance of deployed array in normal porcine lung.

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Fig. 2A. —Gross appearance of two radiofrequency ablation lesions in normal lung tissue. Photographs show lesions that were created with 3.5-cm-diameter array stepped up to 75 (A) and 70 (B) W, with total treatment times of 12 and 10 min, respectively. Baseline impedance values were 120 and 59 ${Omega}$ , respectively.

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Fig. 2B. —Gross appearance of two radiofrequency ablation lesions in normal lung tissue. Photographs show lesions that were created with 3.5-cm-diameter array stepped up to 75 (A) and 70 (B) W, with total treatment times of 12 and 10 min, respectively. Baseline impedance values were 120 and 59 ${Omega}$ , respectively.

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Fig. 3A. —Lesion shown in Figure 2A. Coronal CT scan (A), T1-weighted fast spin-echo MR image (B), and T2-weighted fast spin-echo MR image (C) of lesion. Rectangular box in C identifies region from which tissue specimen was obtained for histology shown in Figure 4.

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Fig. 3B. —Lesion shown in Figure 2A. Coronal CT scan (A), T1-weighted fast spin-echo MR image (B), and T2-weighted fast spin-echo MR image (C) of lesion. Rectangular box in C identifies region from which tissue specimen was obtained for histology shown in Figure 4.

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Fig. 3C. —Lesion shown in Figure 2A. Coronal CT scan (A), T1-weighted fast spin-echo MR image (B), and T2-weighted fast spin-echo MR image (C) of lesion. Rectangular box in C identifies region from which tissue specimen was obtained for histology shown in Figure 4.

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Fig. 4. —Photograph of histology section from lesion shown in Figure 3A, 3B, 3C. Section was taken from tissues identified in Figure 3C (box on T2-weighted image). I = inner zone, O = outer zone, and NML = normal parenchyma.

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Fig. 5. —Photograph shows gross appearance of small hole (arrow) left by tine of array of electrode that pierced left ventricle.

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