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CT and MRI Features of Pure Acinar Cell Carcinoma of the Pancreas in Adults

Servet Tatli1,2, Koenraad J. Mortele1, Angela D. Levy3,4, Jonathan N. Glickman5, Pablo R. Ros1, Peter A. Banks6 and Stuart G. Silverman1

1 Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115.
2 Department of Radiology, Dana Farber Cancer Institute, Boston, MA 02115.
3 Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC.
4 Department of Radiology, Uniformed Services University of Health Sciences, Bethesda, MD.
5 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
6 Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.



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Fig. 1. 63-year-old man with history of prostate cancer who was found to have pancreatic mass on chest CT scan obtained for evaluation of shortness of breath. Unenhanced CT image of pancreas shows oval, homogeneous mass (arrows) in pancreatic tail. Note exophytic location of well-defined mass.

 


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Fig. 2A. 55-year-old man who presented with chest tightness. Axial CT scan of upper abdomen shows homogeneously enhancing, solid mass (arrows) in pancreatic head.

 


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Fig. 2B. 55-year-old man who presented with chest tightness. Axial CT scan of pancreatic body shows well-defined, round associated pancreatic duct dilatation (arrows).

 


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Fig. 3. 66-year-old man who presented with epigastric mass (arrows), jaundice, and pruritus. Axial CT scan shows large, well-marginated, heterogeneous mass arising from pancreatic head. Note central necrotic and peripheral solid areas.

 


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Fig. 4A. 66-year-old woman who presented with back pain. Conventional abdominal radiograph shows coarse calcifications (arrows) in left upper quadrant.

 


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Fig. 4B. 66-year-old woman who presented with back pain. Enhanced CT scan reveals large cystic mass (arrows) with peripheral solid component and thick peripheral calcification.

 


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Fig. 5A. 55-year-old woman who presented with intermittent epigastric pain over 3-year period. Axial CT scan shows well-marginated exophytic mass (arrows) in pancreatic head with central necrosis and hypovascular enhancement in peripheral component. Note punctate calcification (arrowhead).

 


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Fig. 5B. 55-year-old woman who presented with intermittent epigastric pain over 3-year period. Coronal reformation of CT scan nicely displays mass (arrows).

 


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Fig. 5C. 55-year-old woman who presented with intermittent epigastric pain over 3-year period. Gross pathology photograph shows well-marginated solid tumor (lower left).

 


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Fig. 5D. 55-year-old woman who presented with intermittent epigastric pain over 3-year period. Low-power photomicrograph shows nests of tumor cells separated by thin fibrovascular septa. (H and E, x40)

 


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Fig. 5E. 55-year-old woman who presented with intermittent epigastric pain over 3-year period. High-power view of tumor cells shows round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm containing zymogen granules. (H and E, x200)

 


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Fig. 6A. 48-year-old man who presented with epigastric pain and elevated serum amylase level. Axial T2-weighted MR image shows mass (arrow) in pancreatic body that is slightly hyperintense.

 


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Fig. 6B. 48-year-old man who presented with epigastric pain and elevated serum amylase level. Axial T1-weighted MR image shows that mass (arrow) is hypointense.

 


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Fig. 6C. 48-year-old man who presented with epigastric pain and elevated serum amylase level. After IV injection of gadolinium, no clear enhancement of mass (arrow) is seen on axial fat-suppressed gradient-recalled echo arterial (C) and portal venous (D) phase images.

 


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Fig. 6D. 48-year-old man who presented with epigastric pain and elevated serum amylase level. After IV injection of gadolinium, no clear enhancement of mass (arrow) is seen on axial fat-suppressed gradient-recalled echo arterial (C) and portal venous (D) phase images.

 


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Fig. 7A. 78-year-old woman who presented with right upper quadrant pain. Upper gastrointestinal series shows that mass is invading second portion of duodenum (arrows). Note markedly narrowed second portion of duodenum (thin vertical collection of barium anteriorly) (arrowheads).

 


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Fig. 7B. 78-year-old woman who presented with right upper quadrant pain. CT scan reveals duodenal invasion (arrows).

 


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Fig. 8A. 71-year-old man with 3-month history of swelling and pain in peripheral joints, painful cutaneous lumps, and fever. Radiograph of right hand shows lytic lesions (arrows) in phalanges, especially in fifth finger, which most likely represent areas of fat necrosis rather than metastasis.

 


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Fig. 8B. 71-year-old man with 3-month history of swelling and pain in peripheral joints, painful cutaneous lumps, and fever. Photograph shows skin nodule (arrow) at knee that was proven to be fat necrosis.

 


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Fig. 8C. 71-year-old man with 3-month history of swelling and pain in peripheral joints, painful cutaneous lumps, and fever. Axial CT scan reveals large, exophytic mass (arrow) with central cystic area in pancreatic tail.

 


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Fig. 8D. 71-year-old man with 3-month history of swelling and pain in peripheral joints, painful cutaneous lumps, and fever. Gross pathology photograph of tumor shows central necrosis.

 

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