CT and MRI Features of Pure Acinar Cell Carcinoma of the Pancreas in Adults
Servet Tatli1,2,
Koenraad J. Mortele1,
Angela D. Levy3,4,
Jonathan N. Glickman5,
Pablo R. Ros1,
Peter A. Banks6 and
Stuart G. Silverman1
1 Department of Radiology, Division of Abdominal Imaging and Intervention,
Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston,
MA 02115.
2 Department of Radiology, Dana Farber Cancer Institute, Boston, MA 02115.
3 Department of Radiologic Pathology, Armed Forces Institute of Pathology,
Washington, DC.
4 Department of Radiology, Uniformed Services University of Health Sciences,
Bethesda, MD.
5 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School,
Boston, MA.
6 Division of Gastroenterology, Department of Medicine, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA.

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Fig. 1. 63-year-old man with history of prostate cancer who was found
to have pancreatic mass on chest CT scan obtained for evaluation of shortness
of breath. Unenhanced CT image of pancreas shows oval, homogeneous mass
(arrows) in pancreatic tail. Note exophytic location of well-defined
mass.
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Fig. 2A. 55-year-old man who presented with chest tightness. Axial CT
scan of upper abdomen shows homogeneously enhancing, solid mass
(arrows) in pancreatic head.
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Fig. 2B. 55-year-old man who presented with chest tightness. Axial CT
scan of pancreatic body shows well-defined, round associated pancreatic duct
dilatation (arrows).
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Fig. 3. 66-year-old man who presented with epigastric mass
(arrows), jaundice, and pruritus. Axial CT scan shows large,
well-marginated, heterogeneous mass arising from pancreatic head. Note central
necrotic and peripheral solid areas.
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Fig. 4A. 66-year-old woman who presented with back pain. Conventional
abdominal radiograph shows coarse calcifications (arrows) in left
upper quadrant.
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Fig. 4B. 66-year-old woman who presented with back pain. Enhanced CT
scan reveals large cystic mass (arrows) with peripheral solid
component and thick peripheral calcification.
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Fig. 5A. 55-year-old woman who presented with intermittent epigastric
pain over 3-year period. Axial CT scan shows well-marginated exophytic mass
(arrows) in pancreatic head with central necrosis and hypovascular
enhancement in peripheral component. Note punctate calcification
(arrowhead).
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Fig. 5B. 55-year-old woman who presented with intermittent epigastric
pain over 3-year period. Coronal reformation of CT scan nicely displays mass
(arrows).
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Fig. 5C. 55-year-old woman who presented with intermittent epigastric
pain over 3-year period. Gross pathology photograph shows well-marginated
solid tumor (lower left).
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Fig. 5D. 55-year-old woman who presented with intermittent epigastric
pain over 3-year period. Low-power photomicrograph shows nests of tumor cells
separated by thin fibrovascular septa. (H and E, x40)
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Fig. 5E. 55-year-old woman who presented with intermittent epigastric
pain over 3-year period. High-power view of tumor cells shows round nuclei,
prominent nucleoli, and abundant eosinophilic cytoplasm containing zymogen
granules. (H and E, x200)
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Fig. 6A. 48-year-old man who presented with epigastric pain and
elevated serum amylase level. Axial T2-weighted MR image shows mass
(arrow) in pancreatic body that is slightly hyperintense.
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Fig. 6B. 48-year-old man who presented with epigastric pain and
elevated serum amylase level. Axial T1-weighted MR image shows that mass
(arrow) is hypointense.
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Fig. 6C. 48-year-old man who presented with epigastric pain and
elevated serum amylase level. After IV injection of gadolinium, no clear
enhancement of mass (arrow) is seen on axial fat-suppressed
gradient-recalled echo arterial (C) and portal venous (D) phase
images.
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Fig. 6D. 48-year-old man who presented with epigastric pain and
elevated serum amylase level. After IV injection of gadolinium, no clear
enhancement of mass (arrow) is seen on axial fat-suppressed
gradient-recalled echo arterial (C) and portal venous (D) phase
images.
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Fig. 7A. 78-year-old woman who presented with right upper quadrant
pain. Upper gastrointestinal series shows that mass is invading second portion
of duodenum (arrows). Note markedly narrowed second portion of
duodenum (thin vertical collection of barium anteriorly)
(arrowheads).
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Fig. 7B. 78-year-old woman who presented with right upper quadrant
pain. CT scan reveals duodenal invasion (arrows).
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Fig. 8A. 71-year-old man with 3-month history of swelling and pain in
peripheral joints, painful cutaneous lumps, and fever. Radiograph of right
hand shows lytic lesions (arrows) in phalanges, especially in fifth
finger, which most likely represent areas of fat necrosis rather than
metastasis.
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Fig. 8B. 71-year-old man with 3-month history of swelling and pain in
peripheral joints, painful cutaneous lumps, and fever. Photograph shows skin
nodule (arrow) at knee that was proven to be fat necrosis.
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Fig. 8C. 71-year-old man with 3-month history of swelling and pain in
peripheral joints, painful cutaneous lumps, and fever. Axial CT scan reveals
large, exophytic mass (arrow) with central cystic area in pancreatic
tail.
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Fig. 8D. 71-year-old man with 3-month history of swelling and pain in
peripheral joints, painful cutaneous lumps, and fever. Gross pathology
photograph of tumor shows central necrosis.
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Copyright © 2005 by the American Roentgen Ray Society.