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Full-Body Cardiovascular and Tumor MRI for Early Detection of Disease: Feasibility and Initial Experience in 298 Subjects

¹ All authors: Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, Essen 45122, Germany.

View larger version (116K): [in a new window]   Fig. 1A. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 2, 3A, 3B, 3C, 4A, 4B, 4C, 4D, 5). MRI assessment of brain can be completed within 10 min. MR images of brain parenchyma show normal findings: T1-weighted FLASH image (A), T2-weighted turbo spin-echo image (B), and FLAIR image (C).

View larger version (114K): [in a new window]   Fig. 1B. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 2, 3A, 3B, 3C, 4A, 4B, 4C, 4D, 5). MRI assessment of brain can be completed within 10 min. MR images of brain parenchyma show normal findings: T1-weighted FLASH image (A), T2-weighted turbo spin-echo image (B), and FLAIR image (C).

View larger version (119K): [in a new window]   Fig. 1C. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 2, 3A, 3B, 3C, 4A, 4B, 4C, 4D, 5). MRI assessment of brain can be completed within 10 min. MR images of brain parenchyma show normal findings: T1-weighted FLASH image (A), T2-weighted turbo spin-echo image (B), and FLAIR image (C).

View larger version (107K): [in a new window]   Fig. 1D. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 2, 3A, 3B, 3C, 4A, 4B, 4C, 4D, 5). MRI assessment of brain can be completed within 10 min. Diffusion-weighted image reveals normal function.

View larger version (73K): [in a new window]   Fig. 1E. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 2, 3A, 3B, 3C, 4A, 4B, 4C, 4D, 5). MRI assessment of brain can be completed within 10 min. Time-of-flight image shows that arterial morphology is normal.

View larger version (23K): [in a new window]   Fig. 2. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 1A, 1B, 1C, 1D, 1E and 3A, 3B, 3C, 4A, 4B, 4C, 4D, 5). Whole-body angiogram (data acquisition time, 72 sec) shows normal findings.

View larger version (129K): [in a new window]   Fig. 3A. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 1A, 1B, 1C, 1D, 1E, 2, 4A, 4B, 4C, 4D, and 5). Two-chamber (A), four-chamber (B), short-axis (C) views show normal late enhancement study of heart.

View larger version (131K): [in a new window]   Fig. 3B. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 1A, 1B, 1C, 1D, 1E, 2, 4A, 4B, 4C, 4D, and 5). Two-chamber (A), four-chamber (B), short-axis (C) views show normal late enhancement study of heart.

View larger version (107K): [in a new window]   Fig. 3C. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 1A, 1B, 1C, 1D, 1E, 2, 4A, 4B, 4C, 4D, and 5). Two-chamber (A), four-chamber (B), short-axis (C) views show normal late enhancement study of heart.

View larger version (150K): [in a new window]   Fig. 4A. —Steady-state free precession (trueFISP) cine of the heart in 51-year-old male smoker with hyperlipidemia (same subject as in Figs 1A, 1B, 1C, 1D, 1E, 2, 3A, 3B, 3C and 5). Two-chamber view obtained during systole (A), four-chamber view obtained during systole (B), shortaxis view obtained during systole (C), and short-axis view obtained during diastole (D) show normal findings.

View larger version (115K): [in a new window]   Fig. 4B. —Steady-state free precession (trueFISP) cine of the heart in 51-year-old male smoker with hyperlipidemia (same subject as in Figs 1A, 1B, 1C, 1D, 1E, 2, 3A, 3B, 3C and 5). Two-chamber view obtained during systole (A), four-chamber view obtained during systole (B), shortaxis view obtained during systole (C), and short-axis view obtained during diastole (D) show normal findings.

View larger version (109K): [in a new window]   Fig. 4C. —Steady-state free precession (trueFISP) cine of the heart in 51-year-old male smoker with hyperlipidemia (same subject as in Figs 1A, 1B, 1C, 1D, 1E, 2, 3A, 3B, 3C and 5). Two-chamber view obtained during systole (A), four-chamber view obtained during systole (B), shortaxis view obtained during systole (C), and short-axis view obtained during diastole (D) show normal findings.

View larger version (118K): [in a new window]   Fig. 4D. —Steady-state free precession (trueFISP) cine of the heart in 51-year-old male smoker with hyperlipidemia (same subject as in Figs 1A, 1B, 1C, 1D, 1E, 2, 3A, 3B, 3C and 5). Two-chamber view obtained during systole (A), four-chamber view obtained during systole (B), shortaxis view obtained during systole (C), and short-axis view obtained during diastole (D) show normal findings.

View larger version (113K): [in a new window]   Fig. 5. —51-year-old male smoker with hyperlipidemia (same subject as in Figs. 1A, 1B, 1C, 1D, 1E, 2, 3A, 3B, 3C, 4A, 4B, 4C, 4D). Source MR colonography image from 96-slice 3D coronal gradient-echo data set, acquired 60 sec after IV contrast injection shows normal findings (acquisition time, 24 sec). Rectal enema with water renders colonic lumen (asterisk) dark.

View larger version (111K): [in a new window]   Fig. 6A. —48-year-old man with no known risk factors for atherosclerosis. T1-weighted (A), FLAIR (B), T2-weighted fast spin-echo (C), and diffusion-weighted (D) images show small lacunar infarction in right caudate nucleus (arrows). E, Maximum-intensity-projection 3D time-of-flight angiogram shows normal findings for arterial system.

View larger version (137K): [in a new window]   Fig. 6B. —48-year-old man with no known risk factors for atherosclerosis. T1-weighted (A), FLAIR (B), T2-weighted fast spin-echo (C), and diffusion-weighted (D) images show small lacunar infarction in right caudate nucleus (arrows). E, Maximum-intensity-projection 3D time-of-flight angiogram shows normal findings for arterial system.

View larger version (140K): [in a new window]   Fig. 6C. —48-year-old man with no known risk factors for atherosclerosis. T1-weighted (A), FLAIR (B), T2-weighted fast spin-echo (C), and diffusion-weighted (D) images show small lacunar infarction in right caudate nucleus (arrows). E, Maximum-intensity-projection 3D time-of-flight angiogram shows normal findings for arterial system.

View larger version (121K): [in a new window]   Fig. 6D. —48-year-old man with no known risk factors for atherosclerosis. T1-weighted (A), FLAIR (B), T2-weighted fast spin-echo (C), and diffusion-weighted (D) images show small lacunar infarction in right caudate nucleus (arrows).

View larger version (82K): [in a new window]   Fig. 6E. —48-year-old man with no known risk factors for atherosclerosis. Maximum-intensity-projection 3D time-of-flight angiogram shows normal findings for arterial system.

View larger version (96K): [in a new window]   Fig. 7. —52-year-old man who is a heavy smoker. Maximum-intensity-projection image of upper thigh obtained from contrast-enhanced 3D gradient-echo MR angiography data set shows that left superior femoral artery has complex narrowing (arrow), which was shown to be focal dissection.

View larger version (122K): [in a new window]   Fig. 8A. —56-year-old male nonsmoker. MR HASTE (A and C) and respective MDCT (B and D) images show benign partially calcified lesions in lower lobes (arrows).

View larger version (135K): [in a new window]   Fig. 8B. —56-year-old male nonsmoker. MR HASTE (A and C) and respective MDCT (B and D) images show benign partially calcified lesions in lower lobes (arrows).

View larger version (119K): [in a new window]   Fig. 8C. —56-year-old male nonsmoker. MR HASTE (A and C) and respective MDCT (B and D) images show benign partially calcified lesions in lower lobes (arrows).

View larger version (127K): [in a new window]   Fig. 8D. —56-year-old male nonsmoker. MR HASTE (A and C) and respective MDCT (B and D) images show benign partially calcified lesions in lower lobes (arrows).

View larger version (74K): [in a new window]   Fig. 9A. —73-year-old man with history of polypectomy. Sagittal reformation image (A) and coronal source image (B) of 3D gradient-echo data set show small polyp in ascending colon (arrows).

View larger version (147K): [in a new window]   Fig. 9B. —73-year-old man with history of polypectomy. Sagittal reformation image (A) and coronal source image (B) of 3D gradient-echo data set show small polyp in ascending colon (arrows).

View larger version (141K): [in a new window]   Fig. 9C. —73-year-old man with history of polypectomy. Endoscopic view also shows small polyp in ascending colon (arrow).

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