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MRI of Fat Distribution in a Mouse Model of Lysosomal Acid Lipase Deficiency

Hong Du1,2, Bernard J. Dardzinski1,2,3, Kendall J. O'Brien3 and Lane F. Donnelly1,2,3

1 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039.
2 University of Cincinnati College of Medicine, Cincinnati, OH.
3 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039.



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  		Fig. 1. —Photograph of control (left) and lysosomal acid lipase–deficient mouse (right), both approximately 30 weeks old. Depleted subcutaneous adipose tissue, depleted omentum, and markedly enlarged and yellow liver (large arrows) are seen in deficient mouse; normal liver (small arrows) and normal omentum (arrowheads) are seen in control mouse.

 


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  		Fig. 2A. —Coronal T1-weighted spin-echo MR images obtained with volume segmentation for total adipose tissue. Contiguous images of 30-week-old control mouse show red regions of interest that denote area of total adipose tissue.

 


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  		Fig. 2B. —Coronal T1-weighted spin-echo MR images obtained with volume segmentation for total adipose tissue. Contiguous images of 30-week-old lysosomal acid lipase–deficient mouse show red regions of interest that denote area of total adipose tissue. Liver (L) is larger than that in control mouse. Decreased subcutaneous fat and increased fat deposition in bowel wall (arrows) are seen.

 


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  		Fig. 3A. —Coronal T1-weighted spin-echo MR images obtained with volume segmentation for intraabdominal adipose tissue. Contiguous images of 30-week-old control mouse show red regions of interest that denote area of intraabominal adipose tissue. Retroperitoneal (arrows) and reproductive (arrowheads) adipose tissue is seen.

 


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  		Fig. 3B. —Coronal T1-weighted spin-echo MR images obtained with volume segmentation for intraabdominal adipose tissue. Contiguous images of 30-week-old lysosomal acid lipase–deficient mouse show red regions of interest that denote area of intraabdominal adipose tissue. Retroperitoneal and reproductive adipose tissue is less than that in control mouse, and fat deposition in bowel wall (arrows) is greater than that in control mouse. Hepatomegaly is present also.

 


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  		Fig. 4A. —Coronal T1-weighted spin-echo MR images obtained with volume segmentation for liver. Contiguous images of 30-week-old control mouse show red regions of interest that denote area of liver.

 


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  		Fig. 4B. —Coronal T1-weighted spin-echo MR images obtained with volume segmentation for liver. Contiguous images of 30-week-old lysosomal acid lipase–deficient mouse show red regions of interest that denote area of liver. Liver is markedly larger in lysosomal acid lipase–deficient mouse than that in control mouse.

 

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