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Contrast-Enhanced Sonography with SonoVue: Enhancement Patterns of Benign Focal Liver Lesions and Correlation with Dynamic Gadobenate Dimeglumine–Enhanced MRI

Paolo Ricci1, Andrea Laghi1, Vito Cantisani1, Pasquale Paolantonio1, Sara Pacella1, Elisa Pagliara1, Federico Arduini1, Valerio Pasqualini1, Francesca Trippa1, Marzia Filpo1 and Roberto Passariello1

1 All authors: Dipartimento di Scienze Radiologiche, Policlinico Umberto I –Università "La Sapienza," V. le Regina Elena, Rome 324 00161, Italy.



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  		Fig. 1A. —56-year-old man with hepatic hemangioma. Contrast-enhanced sonograms show globular peripheral enhancement of lesion during arterial phase (A) and incomplete filling-in during portal and late phases (B).

 


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  		Fig. 1B. —56-year-old man with hepatic hemangioma. Contrast-enhanced sonograms show globular peripheral enhancement of lesion during arterial phase (A) and incomplete filling-in during portal and late phases (B).

 


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  		Fig. 1C. —56-year-old man with hepatic hemangioma. Gadobenate dimeglumine–enhanced MR images show lesion presenting same contrast behavior.

 


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  		Fig. 1D. —56-year-old man with hepatic hemangioma. Gadobenate dimeglumine–enhanced MR images show lesion presenting same contrast behavior.

 


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  		Fig. 2A. —28-year-old woman with focal nodular hyperplasia. Contrast-enhanced sonogram shows early homogeneous enhancement during arterial phase.

 


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  		Fig. 2B. —28-year-old woman with focal nodular hyperplasia. Contrast-enhanced sonograms show lesion appears slightly hyperechoic and hysoechoic (having same enhancement as surrounding liver parenchyma in portal and late phases) during portal (B) and late (C) phases.

 


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  		Fig. 2C. —28-year-old woman with focal nodular hyperplasia. Contrast-enhanced sonograms show lesion appears slightly hyperechoic and hysoechoic (having same enhancement as surrounding liver parenchyma in portal and late phases) during portal (B) and late (C) phases.

 


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  		Fig. 2D. —28-year-old woman with focal nodular hyperplasia. Gadobenate dimeglumine–enhanced MR images reveal that lesion appears markedly hyperintense during arterial phase (D) and hysointense during portal (E) and late phases.

 


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  		Fig. 2E. —28-year-old woman with focal nodular hyperplasia. Gadobenate dimeglumine–enhanced MR images reveal that lesion appears markedly hyperintense during arterial phase (D) and hysointense during portal (E) and late phases.

 


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  		Fig. 2F. —28-year-old woman with focal nodular hyperplasia. Gadobenate dimeglumine–enhanced MR image after 1 hr (hepatobiliary phase) shows that lesions remain isointense compared with liver parenchyma.

 


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  		Fig. 3A. —40-year-old woman with hepatocellular adenoma. Contrast-enhanced sonograms show early, intense, and homogeneous wash-in during arterial phase (A) followed by fast washout during portal phase (B).

 


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  		Fig. 3B. —40-year-old woman with hepatocellular adenoma. Contrast-enhanced sonograms show early, intense, and homogeneous wash-in during arterial phase (A) followed by fast washout during portal phase (B).

 


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  		Fig. 3C. —40-year-old woman with hepatocellular adenoma. Gadobenate dimeglumine–enhanced MR images show same contrast behavior during arterial (C) and portal (D) phases. Arrow indicates lesion.

 


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  		Fig. 3D. —40-year-old woman with hepatocellular adenoma. Gadobenate dimeglumine–enhanced MR images show same contrast behavior during arterial (C) and portal (D) phases. Arrow indicates lesion.

 


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  		Fig. 3E. —40-year-old woman with hepatocellular adenoma. Gadobenate dimeglumine–enhanced MR image after 1 hr (hepatobiliary phase) shows lesions (arrow) appear hypointense compared with liver parenchyma.

 

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