Superficial Neurofibroma: A Lesion with Unique MRI Characteristics in Patients with Neurofibromatosis Type 1
Ruth Lim1,2,
Diego Jaramillo3,
Tina Young Poussaint4,
Yuchiao Chang5 and
Bruce Korf6
1 Department of Radiology, Massachusetts General Hospital, 55 Fruit St., Boston,
MA 02150.
2 Present address: Department of Radiology, Brigham and Women's Hospital,
Boston, MA 02115.
3 Department of Radiology, Children's Hospital of Philadelphia, 34th Street and
Civic Center Blvd., Philadelphia, PA 19104.
4 Department of Radiology, Children's Hospital Boston, Boston, MA 02115.
5 Department of Medicine, Massachusetts General Hospital, Boston, MA
02114.
6 Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
35294.
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Fig. 1. —10-year-old girl with superficial neurofibroma of knee. Sagittal
STIR image (TR/TE, 6,000/35; inversion time, 150 msec; echo-train length, 8)
shows skin involvement (arrow) located anterior to insertion of
patellar tendon.
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Fig. 2. —14-year-old girl with superficial neurofibroma of posterior right
thigh without skin involvement. Axial STIR image shows that lesion abuts deep
fascia and insinuates itself along lateral intermuscular septum but spares
adjacent biceps femoris muscle (asterisk). Arrow points to normal
position of lateral intermuscular septum on normal side.
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Fig. 3A. —24-year-old man with deep, nodular neurofibroma of sciatic nerves in
pelvis and gluteal region. Coronal STIR image shows well-defined borders
(arrows).
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Fig. 4A. —29-year-old woman with deep neurofibroma of leg. Coronal STIR image
shows well-defined borders (arrows).
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Fig. 5. —39-year-old woman with superficial neurofibroma of lower back.
Coronal STIR image shows poorly defined borders (arrows). G = gluteal
muscles.
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Fig. 6A. —28-year-old woman with superficial neurofibroma of leg. Coronal STIR
image shows poorly defined borders (arrows).
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Fig. 4B. —29-year-old woman with deep neurofibroma of leg. Coronal STIR image
shows nodular morphology (arrow).
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Fig. 7. —3-year-old boy with deep neurofibroma of thigh. Coronal STIR image
shows that superiorly, there are numerous fascicles (open arrow) that
divide distally into multiple branches (solid arrows).
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Fig. 8. —51-year-old woman with extensive superficial neurofibroma of leg.
Coronal STIR image shows diffuse morphology. C = calcaneus.
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Fig. 3B. —24-year-old man with deep, nodular neurofibroma of sciatic nerves in
pelvis and gluteal region. Axial STIR image shows targetlike (arrows)
signal intensity.
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Fig. 6B. —28-year-old woman with superficial neurofibroma of leg. Axial STIR
image shows homogeneous signal intensity (arrows).
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Fig. 9. —54-year-old man with superficial neurofibroma of calf. Axial STIR
image shows heterogeneous signal intensity (large arrow). Flow voids
are seen within lesion (small arrow).
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Fig. 10. —33-year-old man with superficial neurofibroma of right
posterolateral neck. Axial STIR image shows multiple flow voids
(arrows) consistent with blood vessels.
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Fig. 11. —18-year-old man with deep neurofibroma of hand. Coronal STIR image
shows multiple serpentine structures (arrows) resembling vascular
malformation. T = thumb.
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Copyright © 2005 by the American Roentgen Ray Society.
