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Multifocal Micronodular Pneumocyte Hyperplasia in Tuberous Sclerosis

Ross L. Ristagno1, Paul W. Biddinger2, Elsira M. Pina3 and Cris A. Meyer1

1 Department of Radiology, University Hospital, ML 0761, 234 Goodman St., Cincinnati, OH 45267-0761.
2 Department Of Pathology, University Hospital, Cincinnati, Oh 45267-0761.
3 Department of Pulmonary Medicine, University Hospital, Cincinnati, OH 45267-0761.



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  		Fig. 1A. —51-year-old man with multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. Chest radiograph reveals bilateral diffuse fine nodular opacities.

 


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  		Fig. 1B. —51-year-old man with multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. Chest radiograph detail view reveals bilateral diffuse fine nodular opacities.

 


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  		Fig. 1C. —51-year-old man with multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. High-resolution CT through upper lobes shows 1- to 3-mm nodules (white arrows) with random distribution in secondary lobule and intralobular interstitial thickening.

 


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  		Fig. 1D. —51-year-old man with multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. High-resolution CT through right lower lung shows 1- to 3-mm nodules (white arrow) with random distribution in secondary lobule.

 


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  		Fig. 1E. —51-year-old man with multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. Low-power photomicrograph of the histopathologic section shows irregular, nodular foci of interstitial thickening and pneumocyte hyperplasia (black arrows). Surrounding airspaces contain abundant macrophages.

 


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  		Fig. 1F. —51-year-old man with multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis. High-power photomicrograph of histopathologic section reveals nodule with fibrotic interstitial septa covered by cuboidal type II pneumocytes that show variable atypia (black arrows).

 

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