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MRI of Metaplastic Carcinoma of the Breast

Martín Velasco1, Gorane Santamaría1, Sergi Ganau1, Blanca Farrús2, Gabriel Zanón3, Cleofé Romagosa4 and Pedro Luis Fernández4

1 Department of Radiology, Hospital Clínic and University of Barcelona Medical School, Villarroel, 170, 08036 Barcelona, Spain.
2 Department of Radiotherapy Oncology, Hospital Clínic and University of Barcelona Medical School, 08036 Barcelona, Spain.
3 Department of Obstetrics and Gynecology, Hospital Clínic and University of Barcelona Medical School, 08036 Barcelona, Spain.
4 Department of Pathology, Hospital Clínic and University of Barcelona Medical School, 08036 Barcelona, Spain.



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Fig. 1. 57-year-old woman (patient 9) with carcinoma and chondroid metaplasia in right breast (left). Mediolateral oblique mammogram shows 1.8-cm lobular mass with irregular margins and associated microcalcifications (arrow) in upper outer quadrant.

 


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Fig. 2. 82-year-old woman (patient 2) with squamous large cell keratinizing carcinoma in right breast (right). Coronal T2-weighted turbo spin-echo image (TR/TE, 8,256/132) shows lobular mass with homogeneous high signal intensity (arrow) in lower inner quadrant.

 


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Fig. 3. 75-year-old woman (patient 11) with carcinosarcoma in left breast (left). Coronal T2-weighted turbo spin-echo image (TR/TE, 8,256/132) shows lobular mass with areas of intratumoral hypersignal (arrows) in lower outer quadrant.

 


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Fig. 4. 65-year-old woman (patient 7) with carcinoma and chondroid metaplasia in left breast (right). Coronal T2-weighted turbo spin-echo image (TR/TE, 8,256/132) shows lobular mass isointense relative to surrounding fibroglandular tissue (arrows) in upper outer quadrant.

 


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Fig. 5A. 41-year-old woman (patient 10) with carcinoma and chondroid metaplasia in upper outer quadrant of right breast. Coronal FLASH 3D T1-weighted image (TR/TE, 14/7) at early phase after administration of gadolinium shows ringlike tumor enhancement (arrows).

 


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Fig. 5B. 41-year-old woman (patient 10) with carcinoma and chondroid metaplasia in upper outer quadrant of right breast. Photograph of surgical specimen shows well-delimited tumor with whitish cut surface and central necrosis (arrows).

 


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Fig. 5C. 41-year-old woman (patient 10) with carcinoma and chondroid metaplasia in upper outer quadrant of right breast. Low-power photomicrograph from surgical specimen shows necrosis (N) and thin ring of viable tumor (T). (H and E, x40)

 


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Fig. 5D. 41-year-old woman (patient 10) with carcinoma and chondroid metaplasia in upper outer quadrant of right breast. High-magnification photomicrograph shows chondroid metaplasia with basophilic intercellular matrix and neoplastic cells that have chondroid appearance. (H and E, x600)

 

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