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MR Quantification of the Washout Changes in Breast Tumors Under Preoperative Chemotherapy: Feasibility and Preliminary Results

¹ Département d'Imagerie, Institut Curie, 26, rue d'Ulm, Paris 75005, France.
² Department d'biostatistique, Institut Curie, Paris, France.

View larger version (152K): [in a new window]   Fig. 1A. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Precontrast sagittal T1 fast spoiled gradient-recalled echo image (TR/TE, 11/4.2; time of acquisition, 45 sec; number of excitations, 1; section thickness, 4 mm; matrix size, 512 x 192; field of view, 24 x 19.2 cm) shows round low-signal lesion (arrow).

View larger version (143K): [in a new window]   Fig. 1B. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Postcontrast sagittal T1 fast spoiled gradient-recalled echo image (11/4.2; time of acquisition, 45 sec; number of excitations, 1; section thickness, 4 mm; matrix size, 512 x 192; field of view, 24 x 19.2 cm) from acquisitions at 1 min 30 sec after contrast administration shows early uptake of lesion.

View larger version (150K): [in a new window]   Fig. 1C. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Late postcontrast sagittal T1 fast spoiled gradient-recalled echo image shows peripheral decrease of signal (arrows).

View larger version (110K): [in a new window]   Fig. 1D. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Parametric image created by subtraction of signal at 7 min 30 sec from maximum signal in each pixel during dynamic acquisition shows regions of interest 1 and 2. Formula used to create image is as follows: W = [Smax – S(7 min 30 sec)].

View larger version (17K): [in a new window]   Fig. 1E. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Graph shows two signal-to-time curves are given within two regions of interest (ROI): ROI 1 is in bright part of tumor on parametric image (with washout), and ROI 2 in dark part of lesion (no washout).

View larger version (63K): [in a new window]   Fig. 1F. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Parametric washout image shows tumor is isolated from rest of breast. Surrounding pixels (arrows) correspond to washout value smaller than 23 (i.e., cutoff value chosen by observer) and were therefore excluded from volume processing.

View larger version (48K): [in a new window]   Fig. 1G. —45-year-old woman with 3-cm clinical lesion in lower quadrants of breast (case 8). Applying cutoff and processing volume of remaining pixels resulted in this parametric washout image.

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