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MDCT of Hypervascular Hepatocellular Carcinomas: A Prospective Study Using Contrast Materials with Different Iodine Concentrations

¹ Department of Radiology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
² Department of Radiology, Kinki University Nara Hospital, Nara 630-0293, Japan.

View larger version (11K): [in a new window]   Fig. 1A. —Graphs show time–enhancement curves of abdominal aorta, hepatic parenchyma, and main portal vein after start of contrast material injection in group A (solid line) and group B (dotted line). Bars indicate SEs. Aortic enhancement was significantly greater in group A than group B during all phases.

View larger version (11K): [in a new window]   Fig. 1B. —Graphs show time–enhancement curves of abdominal aorta, hepatic parenchyma, and main portal vein after start of contrast material injection in group A (solid line) and group B (dotted line). Bars indicate SEs. Hepatic enhancement was significantly greater in group A than group B at 40, 60, and 180 sec.

View larger version (13K): [in a new window]   Fig. 1C. —Graphs show time–enhancement curves of abdominal aorta, hepatic parenchyma, and main portal vein after start of contrast material injection in group A (solid line) and group B (dotted line). Bars indicate SEs. Enhancement of the portal vein was significantly greater in group A than group B at 60 and 180 sec.

View larger version (12K): [in a new window]   Fig. 2. —Graph shows time–density curves of tumor-to-liver contrast (TLC) values for 27 hypervascular hepatocellular carcinomas in group A (solid line) and group B (dotted line). At 25 sec, there was no significant difference in mean TLC values between groups A and B. At 40 sec, TLC values were significantly higher in group A (p < 0.02). However, there was no significantly difference in mean TLC values between groups A and B at 60 and 180 sec.

View larger version (85K): [in a new window]   Fig. 3. —54-year-old man with hypervascular HCC in segment VIII. His body weight was 63 kg, and 100 mL of 370 mg I/mL contrast material was administered (group A). CT scan obtained during late arterial phase clearly shows tumor of 24 mm with tumor-to-liver contrast of 69 H.

View larger version (79K): [in a new window]   Fig. 4. —60-year-old woman with hypervascular hepatocellular carcinoma in segment II. Her body weight was 62 kg, and 100 mL of 300 mg I/mL contrast material was administered (group B). CT scan obtained during late arterial phase depicts tumor of 20 mm with tumor-to-liver contrast of 35 H.

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