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Lobular Carcinoma In Situ of the Breast Presenting as a Mass

Lauren F. Stein1, Gilat Zisman1, Jocelyn A. Rapelyea1, Arnold M. Schwartz2, Bruce Abell3 and Rachel F. Brem1

1 Department of Radiology, The George Washington University Medical Center, 2150 Pennsylvania Ave., Washington, D.C. 20037.
2 Department of Pathology, The George Washington University Medical Center, Washington, D.C. 20037.
3 Department of Surgery, The George Washington University Medical Center, Washington, D.C. 20037.



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  		Fig. 1A. —50-year-old woman with new mammographically detected mass. Right craniocaudal view shows dominant mass (arrow) in upper outer portion of right breast.

 


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  		Fig. 1B. —50-year-old woman with new mammographically detected mass. Mediolateral oblique view shows dominant mass (arrow) in upper outer portion of right breast.

 


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  		Fig. 1C. —50-year-old woman with new mammographically detected mass. High-resolution, real-time sonogram of right breast at 9-o'clock position shows indeterminate, hypoechoic, and microlobulated 6.5 x 6.6-mm nodule.

 


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  		Fig. 1D. —50-year-old woman with new mammographically detected mass. Radiograph of surgical specimen shows well-defined mass.

 


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  		Fig. 1E. —50-year-old woman with new mammographically detected mass. Pathologic image of area of lobular carcinoma in situ (LCIS) with intralobular fibrosis shows uniformity of receptor cells and expression of lobular units. (x200)

 


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  		Fig. 1F. —50-year-old woman with new mammographically detected mass. Pathologic image of immunoreactivity of LCIS for estrogen receptors reveals positive nuclear staining indicative of estrogen receptor expression.

 

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