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Liver Abscess After Percutaneous Radiofrequency Ablation for Hepatocellular Carcinomas: Frequency and Risk Factors

Dongil Choi1, Hyo K. Lim1, Min Ju Kim1, Suk Jung Kim1, Seung Hoon Kim1, Won Jae Lee1, Jae Hoon Lim1, Seung Woon Paik2, Byung Chul Yoo2, Moon Seok Choi2 and Seonwoo Kim3

1 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-dong, Kangnam-ku, Seoul 135-710, South Korea.
2 Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
3 Biostatistics Unit, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.



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Fig. 1A. 75-year-old man with percutaneous radiofrequency ablation of recurrent hepatocellular carcinoma. He had undergone hepaticojejunostomy due to biliary stricture after left hepatectomy for hepatocellular carcinoma. Contrast-enhanced transverse CT scan obtained during arterial phase shows 3.0-cm-diameter hepatocellular carcinoma (arrows) in subcapsular portion of liver segment VI.

 


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Fig. 1B. 75-year-old man with percutaneous radiofrequency ablation of recurrent hepatocellular carcinoma. He had undergone hepaticojejunostomy due to biliary stricture after left hepatectomy for hepatocellular carcinoma. Oblique sonogram obtained 3 days after radiofrequency ablation shows massive hyperechogenicity (arrows) representing air in ablation zone. Patient presented to emergency department with high fever (40°C) and abdominal pain.

 


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Fig. 1C. 75-year-old man with percutaneous radiofrequency ablation of recurrent hepatocellular carcinoma. He had undergone hepaticojejunostomy due to biliary stricture after left hepatectomy for hepatocellular carcinoma. Contrast-enhanced CT scan obtained immediately after sonographic examination shows low-attenuating ablation zone (arrows) containing substantial amount of air (arrowheads), which indicates liver abscess. Cultures with blood were positive for Enterococcus species, which are enteric bacteria. Sepsis developed in this patient, but he recovered with parenteral antibiotics.

 


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Fig. 2A. 61-year-old man with percutaneous radiofrequency ablation of residual hepatocellular carcinoma. He had undergone transcatheter arterial chemoembolization for hepatocellular carcinoma. Contrast-enhanced transverse CT scan, obtained during arterial phase, shows 1.8-cm-diameter residual hepatocellular carcinoma (arrows) in anterior aspect of area of iodized oil retention (arrowheads) in liver segment V.

 


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Fig. 2B. 61-year-old man with percutaneous radiofrequency ablation of residual hepatocellular carcinoma. He had undergone transcatheter arterial chemoembolization for hepatocellular carcinoma. Contrast-enhanced CT scan obtained during arterial phase, 30 days after radiofrequency ablation, shows low-attenuating ablation zone (arrows) with layering enhancing rim (inner enhancing ring and peripheral hypodense ring) (arrowheads). It also contains air bubbles. Patient presented to internal medicine department with low-grade (38°C) fever on scheduled day for follow-up.

 


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Fig. 2C. 61-year-old man with percutaneous radiofrequency ablation of residual hepatocellular carcinoma. He had undergone transcatheter arterial chemoembolization for hepatocellular carcinoma. Contrast-enhanced CT scan obtained during equilibrium phase, 30 days after radiofrequency ablation, shows low-attenuating ablation zone with relatively thick, ringlike enhancement of inner and peripheral zones (arrowheads). This changing target appearance of rim (double ring at arterial phase and single ring at equilibrium phase) is characteristic finding of liver abscess.

 


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Fig. 2D. 61-year-old man with percutaneous radiofrequency ablation of residual hepatocellular carcinoma. He had undergone transcatheter arterial chemoembolization for hepatocellular carcinoma. Contrast-enhanced CT scan obtained 5 months after treatment with IV antibiotics shows abscess has completely resolved, and ablation zone (arrows) shows marked decrease in size.

 

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