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Quantitative Assessment of Colorectal Cancer Perfusion Using MDCT: Inter- and Intraobserver Agreement

¹ Intestinal Imaging Centre, St. Mark's Hospital, Watford Rd., Level 4V, Harrow, Middlesex, HA1 3UJ, United Kingdom.
² Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, United Kingdom.

View larger version (111K): [in a new window]   Fig. 1A —52-year-old man with sigmoid cancer. CT image shows region of interest placed within sigmoid cancer.

View larger version (74K): [in a new window]   Fig. 1B —52-year-old man with sigmoid cancer. Blood flow parametric map that corresponds to A shows heterogeneous flow. Lower area outlined by cursor shows the tumor; upper area outlined by cursor shows vessels used to generate vascular input.

View larger version (15K): [in a new window]   Fig. 2A —Data for blood volume measurements and observer agreement. Scatterplot of blood volume measurements (mL/100 g tissue) shows data for observer 1 (x-axis) and observer 2 (y-axis); line of perfect agreement is shown.

View larger version (8K): [in a new window]   Fig. 2B —Data for blood volume measurements and observer agreement. Agreement plot for blood volume measurements made by observers 1 and 2. Plots the difference between observers' measurements and mean measurements. Top and bottom lines show the 95% limits of agreement; middle line shows mean difference.

View larger version (16K): [in a new window]   Fig. 3A —Data for blood flow measurements and observer agreement. Scatterplot of blood flow measurements (mL/min) shows data for observer 1 (x-axis) and observer 2 (y-axis); line of perfect agreement is shown.

View larger version (7K): [in a new window]   Fig. 3B —Data for blood flow measurements and observer agreement. Agreement plot for blood flow measurements made by observers 1 and 2. Plots the difference between observers' measurements and mean measurements. Top and bottom lines show the 95% limits of agreement; middle line shows mean difference.

View larger version (13K): [in a new window]   Fig. 4A —Data for mean transit time measurements and observer agreement. Scatterplot of mean transit time measurements (sec) shows data for observer 1 (x-axis) and observer 2 (y-axis); line of perfect agreement is shown.

View larger version (9K): [in a new window]   Fig. 4B —Data for mean transit time measurements and observer agreement. Agreement plot for mean transit time measurements made by observers 1 and 2. Plots the difference between observers' measurements and mean measurements. Top and bottom lines show the 95% limits of agreement; middle line shows mean difference.

View larger version (14K): [in a new window]   Fig. 5A —Data for permeability measurements and observer agreement. Scatterplot of permeability measurements (mL/100 g/min) shows data for observer 1 (x-axis) and observer 2 (y-axis); line of perfect agreement is shown.

View larger version (9K): [in a new window]   Fig. 5B —Data for permeability measurements and observer agreement. Agreement plot for permeability measurements made by observers 1 and 2. Plots the difference between observers' measurements and mean measurements. Top and bottom lines show the 95% limits of agreement; middle line shows mean difference.

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