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Invasive Ductal Carcinoma with Fibrotic Focus: Mammographic and Sonographic Findings with Histopathologic Correlation

Shara Millman Oken1, Cecilia L. Mercado2, Lorenzo Memeo3 and Hanina Hibshoosh3

1 Department of Radiology, Breast Imaging, Columbia University Medical Center–New York Presbyterian Hospital, Herbert Irving Pavilion, 161 Fort Washington Ave., 10th Fl., Ste. 1051, New York, NY 10032.
2 Department of Radiology, New York University Cancer Center, New York, NY 10016.
3 Department of Pathology, Columbia University Medical Center–New York Presbyterian Hospital, New York, NY 10032.



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  		Fig. 1A —Mammographic findings of invasive ductal carcinoma with fibrotic focus. Mammogram in 55-year-old woman with invasive ductal carcinoma with fibrotic focus shows spiculated mass with associated pleomorphic calcifications. Skin lesion is marked in lower left-hand corner.

 


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  		Fig. 1B —Mammographic findings of invasive ductal carcinoma with fibrotic focus. Spot compression tangential view in 56-year-old woman with invasive ductal carcinoma with fibrotic focus shows partially circumscribed mass without associated calcifications.

 


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  		Fig. 1C —Mammographic findings of invasive ductal carcinoma with fibrotic focus. Spot compression tangential view over palpable lesion in 51-year-old woman with invasive ductal carcinoma with fibrotic focus shows ill-defined area of high density (arrows).

 


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  		Fig. 2A —Sonographic findings of invasive ductal carcinoma with fibrotic focus. Image in 82-year-old woman with invasive ductal carcinoma shows that echogenic fibrotic focus (arrows) is seen focally and centrally. Fibrotic focus is surrounded by the hypoechoic tumor rim.

 


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  		Fig. 2B —Sonographic findings of invasive ductal carcinoma with fibrotic focus. Image in 69-year-old woman with invasive ductal carcinoma shows that echogenic fibrotic focus (arrow) is seen focally and eccentrically.

 


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  		Fig. 2C —Sonographic findings of invasive ductal carcinoma with fibrotic focus. Image in 63-year-old woman with invasive ductal carcinoma shows echogenic fibrotic focus (arrow) in infiltrative pattern.

 


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  		Fig. 3A —Sonographic findings of fibrotic focus with direct correlation to fibrotic focus seen histologically. Sonogram (A) and photograph of histology specimen (B) in 55-year-old woman with invasive ductal carcinoma show central echogenic fibrotic focus (arrow) that is surrounded by hypoechoic tumor rim. Corresponding mammographic image is shown in Figure 1A.

 


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  		Fig. 3B —Sonographic findings of fibrotic focus with direct correlation to fibrotic focus seen histologically. Sonogram (A) and photograph of histology specimen (B) in 55-year-old woman with invasive ductal carcinoma show central echogenic fibrotic focus (arrow) that is surrounded by hypoechoic tumor rim. Corresponding mammographic image is shown in Figure 1A.

 


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  		Fig. 3C —Sonographic findings of fibrotic focus with direct correlation to fibrotic focus seen histologically. Sonogram (C) and photograph of histology specimen (D) in 56-year-old woman with invasive ductal carcinoma show eccentric fibrotic focus. Corresponding mammographic image is seen in Figure 1B.

 


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  		Fig. 3D —Sonographic findings of fibrotic focus with direct correlation to fibrotic focus seen histologically. Sonogram (C) and photograph of histology specimen (D) in 56-year-old woman with invasive ductal carcinoma show eccentric fibrotic focus. Corresponding mammographic image is seen in Figure 1B.

 


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  		Fig. 4 —Photomicrograph of histology specimen of an invasive ductal carcinoma with fibrotic focus showing the fibrotic focus composed of collagen fibers (black arrow) and fibroblasts (white arrows).

 

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