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Detection of Regional Myocardial Perfusion Deficit Using Rest and Stress Perfusion MRI: A Feasibility Study

¹ Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, Tuebingen 72076, Germany.
² Department of Internal Medicine, Division of Cardiology, Eberhard-Karls-University, Tuebingen 72076, Germany.

View larger version (15K): [in a new window]   Fig. 1 —Sequence diagram of saturation recovery true fast imaging with steady-state precession perfusion sequence. Each data acquisition period is preceded by a nonselective saturation recovery pulse, after which magnetization is allowed to partially recover for 110-120 msec. TI = inversion time.

View larger version (87K): [in a new window]   Fig. 2A —56-year-old woman with 90% stenosis of left anterior descending (LAD) artery. Eight (of 40) representative perfusion MR images are shown for rest (A) and stress (B) examinations. No perfusion deficit can be seen in rest examination; however, after injection of 0.56 mg of dipyridamole/kg of body weight, marked perfusion deficit is visible in anteroseptal part of left ventricle (arrows, B).

View larger version (88K): [in a new window]   Fig. 2B —56-year-old woman with 90% stenosis of left anterior descending (LAD) artery. Eight (of 40) representative perfusion MR images are shown for rest (A) and stress (B) examinations. No perfusion deficit can be seen in rest examination; however, after injection of 0.56 mg of dipyridamole/kg of body weight, marked perfusion deficit is visible in anteroseptal part of left ventricle (arrows, B).

View larger version (170K): [in a new window]   Fig. 2C —56-year-old woman with 90% stenosis of left anterior descending (LAD) artery. Conventional X-ray catheter film (C) displays subtotal LAD stenosis (arrow), and SPECT perfusion image (D) shows correlating perfusion deficit.

View larger version (152K): [in a new window]   Fig. 2D —56-year-old woman with 90% stenosis of left anterior descending (LAD) artery. Conventional X-ray catheter film (C) displays subtotal LAD stenosis (arrow), and SPECT perfusion image (D) shows correlating perfusion deficit.

View larger version (77K): [in a new window]   Fig. 3A —72-year-old man with 80-90% stenosis of left anterior descending (LAD) artery. Eight (of 40) representative perfusion MRI images are shown for rest (A) and stress (B) examinations. At rest, only minor malperfused region is visible in septum of left ventricle (black arrows), whereas in stress examination, perfusion deficit increases significantly (black arrows).

View larger version (84K): [in a new window]   Fig. 3B —72-year-old man with 80-90% stenosis of left anterior descending (LAD) artery. Eight (of 40) representative perfusion MRI images are shown for rest (A) and stress (B) examinations. At rest, only minor malperfused region is visible in septum of left ventricle (black arrows), whereas in stress examination, perfusion deficit increases significantly (black arrows).

View larger version (124K): [in a new window]   Fig. 3C —72-year-old man with 80-90% stenosis of left anterior descending (LAD) artery. Corresponding conventional X-ray catheter image shows LAD stenosis (arrow).

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