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Contrast-Enhanced Dark Lumen PET/CT and MR Colonography in a Rodent Polyp Model: Initial Results with Histopathologic Correlation

¹ Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.
² Institute of Pathology, University Hospital Essen, Essen, Germany.
³ Guerbet Group, Aulnay-sous-Bois, France.

View larger version (130K): [in a new window]   Fig. 1A —Anterior coronal views of fully anesthetized rodent with distal colon polyp. 100% CT image shows polyp (arrow).

View larger version (74K): [in a new window]   Fig. 1B —Anterior coronal views of fully anesthetized rodent with distal colon polyp. Polyp is shown as bright lesion (arrow) in fused PET/CT image.

View larger version (74K): [in a new window]   Fig. 1C —Anterior coronal views of fully anesthetized rodent with distal colon polyp. PET image shows region of increased 18F-FDG uptake with standardized uptake value of 1.7 (arrow).

View larger version (145K): [in a new window]   Fig. 2A —Same rodent as in Figures 1A, 1B, and 1C with distal colon polyp. All images are anterior coronal views of MR colonography data sets (T1-weighted gradient-recalled echo sequence). Polyp (arrow) is difficult to detect on unenhanced image.

View larger version (148K): [in a new window]   Fig. 2B —Same rodent as in Figures 1A, 1B, and 1C with distal colon polyp. All images are anterior coronal views of MR colonography data sets (T1-weighted gradient-recalled echo sequence). Polyp is detectable after contrast agent administration (0.3 mmol/kg gadoterate meglumine) as lesion with focal enhancement (arrow).

View larger version (148K): [in a new window]   Fig. 2C —Same rodent as in Figures 1A, 1B, and 1C with distal colon polyp. All images are anterior coronal views of MR colonography data sets (T1-weighted gradient-recalled echo sequence). Subtraction of unenhanced image from contrast-enhanced image delineates polyp (arrow).

View larger version (148K): [in a new window]   Fig. 2D —Same rodent as in Figures 1A, 1B, and 1C with distal colon polyp. All images are anterior coronal views of MR colonography data sets (T1-weighted gradient-recalled echo sequence). Macroscopic view of opened colon shows polyp (arrow).

View larger version (122K): [in a new window]   Fig. 2E —Same rodent as in Figures 1A, 1B, and 1C with distal colon polyp. All images are anterior coronal views of MR colonography data sets (T1-weighted gradient-recalled echo sequence). Histologic section of tubular polyp (arrowheads) arising from regular colonic wall (arrows) shows minimal branching, hyperchromatic nuclei, and decreased mucin.

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