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Contrast-Enhanced MR Angiography of Subclavian Steal Syndrome: Value of the 2D Time-of-Flight "Localizer" Sign

Niall Sheehy1, Sorcha MacNally1, Clare S. Smith1, Gerard Boyle1, Prakash Madhavan2 and James F. M. Meaney1

1 Department of Diagnostic Imaging, St. James's Hospital, James's St., Dublin 8, Ireland.
2 Department of Vascular Surgery, St. James's Hospital, Dublin 8, Ireland.



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Fig. 1A 63-year-old woman. Reformatted maximum-intensity-projection (A) and sample axial image (B) from 2D time-of-flight localizer in healthy patient undergoing 3D contrast-enhanced MR angiography at our institution. Vertebral arteries are visible, indicating normal flow direction and absence of severe vertebral disease.

 


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Fig. 1B 63-year-old woman. Reformatted maximum-intensity-projection (A) and sample axial image (B) from 2D time-of-flight localizer in healthy patient undergoing 3D contrast-enhanced MR angiography at our institution. Vertebral arteries are visible, indicating normal flow direction and absence of severe vertebral disease.

 


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Fig. 2A 70-year-old woman with suspected subclavian steal syndrome and flow reversal on Doppler sonography. Occlusion is seen within left subclavian artery proximal to veterbral artery origin, shown on high-resolution 3D contrast-enhanced MR angiography (CEMRA) maximum-intensity-projection (MIP) image. The left vertebral artery appears normal (A). The normal left vertebral artery can also be seen on axial reformat of data (B). Corresponding reformatted MIP (C) and axial (D) images from 2D time-of-flight localizer show flow void in left vertebral artery, despite visualization of normal right vertebral artery on 3D CEMRA. This indicates flow reversal within vertebral artery ("localizer" sign).

 


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Fig. 2B 70-year-old woman with suspected subclavian steal syndrome and flow reversal on Doppler sonography. Occlusion is seen within left subclavian artery proximal to veterbral artery origin, shown on high-resolution 3D contrast-enhanced MR angiography (CEMRA) maximum-intensity-projection (MIP) image. The left vertebral artery appears normal (A). The normal left vertebral artery can also be seen on axial reformat of data (B). Corresponding reformatted MIP (C) and axial (D) images from 2D time-of-flight localizer show flow void in left vertebral artery, despite visualization of normal right vertebral artery on 3D CEMRA. This indicates flow reversal within vertebral artery ("localizer" sign).

 


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Fig. 2C 70-year-old woman with suspected subclavian steal syndrome and flow reversal on Doppler sonography. Occlusion is seen within left subclavian artery proximal to veterbral artery origin, shown on high-resolution 3D contrast-enhanced MR angiography (CEMRA) maximum-intensity-projection (MIP) image. The left vertebral artery appears normal (A). The normal left vertebral artery can also be seen on axial reformat of data (B). Corresponding reformatted MIP (C) and axial (D) images from 2D time-of-flight localizer show flow void in left vertebral artery, despite visualization of normal right vertebral artery on 3D CEMRA. This indicates flow reversal within vertebral artery ("localizer" sign).

 


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Fig. 2D 70-year-old woman with suspected subclavian steal syndrome and flow reversal on Doppler sonography. Occlusion is seen within left subclavian artery proximal to veterbral artery origin, shown on high-resolution 3D contrast-enhanced MR angiography (CEMRA) maximum-intensity-projection (MIP) image. The left vertebral artery appears normal (A). The normal left vertebral artery can also be seen on axial reformat of data (B). Corresponding reformatted MIP (C) and axial (D) images from 2D time-of-flight localizer show flow void in left vertebral artery, despite visualization of normal right vertebral artery on 3D CEMRA. This indicates flow reversal within vertebral artery ("localizer" sign).

 


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Fig. 3A Another patient with proximal right subclavian artery stenosis and normal right vertebral artery on 3D contrast-enhanced MR angiography maximum intensity projection (A). Axial image from 2D time-of-flight localizer again shows flow void in right vertebral artery, indicating flow reversal (B).

 


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Fig. 3B Another patient with proximal right subclavian artery stenosis and normal right vertebral artery on 3D contrast-enhanced MR angiography maximum intensity projection (A). Axial image from 2D time-of-flight localizer again shows flow void in right vertebral artery, indicating flow reversal (B).

 


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Fig. 4A Patient shows severe atherosclerotic stenosis of right vertebral artery (A). 2D time-of-flight localizer shows flow void (B), this time due to severe vertebral disease shown on 3D contrast-enhanced MR angiography sequences.

 


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Fig. 4B Patient shows severe atherosclerotic stenosis of right vertebral artery (A). 2D time-of-flight localizer shows flow void (B), this time due to severe vertebral disease shown on 3D contrast-enhanced MR angiography sequences.

 

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