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Sonographically Depicted Breast Clustered Microcysts: Is Follow-Up Appropriate?

Wendie A. Berg1

1 Johns Hopkins Greenspring, 10755 Falls Rd., Suite 440, Lutherville, MD 21093.



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Fig. 1A 52-year-old woman with clustered microcysts. Spot magnification craniocaudal mammogram shows circumscribed, microlobulated mass.

 


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Fig. 1B 52-year-old woman with clustered microcysts. Radial L7.5-12–MHz sonogram (Performa, Acoustic Imaging) shows clustered microcysts. This lesion resolved on follow-up mammography.

 


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Fig. 2A 58-year-old woman on hormone replacement therapy with incidental clustered microcysts on screening sonography (performed due to dense breast tissue). Radial (A) and antiradial (B) L7–13–MHz sonograms with spatial compounding (Elegra, Siemens Medical Solutions) show lesion composed of tiny anechoic foci ranging from 1 to 5 mm. This lesion was stable on 36 months' follow-up.

 


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Fig. 2B 58-year-old woman on hormone replacement therapy with incidental clustered microcysts on screening sonography (performed due to dense breast tissue). Radial (A) and antiradial (B) L7–13–MHz sonograms with spatial compounding (Elegra, Siemens Medical Solutions) show lesion composed of tiny anechoic foci ranging from 1 to 5 mm. This lesion was stable on 36 months' follow-up.

 


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Fig. 3 32-year-old woman with incidental clustered microcysts on screening sonography (performed due to high risk). Transverse L7–13–MHz sonogram with spatial compounding (Elegra, Siemens Medical Solutions) shows clustered microcysts, one of which contains low-level echoes (arrow) due to debris within the fluid—that is, a complicated microcyst. This lesion resolved at 12 months' follow-up.

 


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Fig. 4A 57-year-old woman with palpable mass due to clustered microcysts that enlarged and then regressed on follow-up. Mediolateral oblique mammogram shows indistinctly marginated mass corresponding to palpable abnormality (marked with a radiopaque marker).

 


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Fig. 4B 57-year-old woman with palpable mass due to clustered microcysts that enlarged and then regressed on follow-up. Transverse L5–10–MHz sonogram (equipment details not available) obtained at another institution shows irregular hypoechoic mass considered suspicious, with biopsy initially recommended.

 


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Fig. 4C 57-year-old woman with palpable mass due to clustered microcysts that enlarged and then regressed on follow-up. Transverse L7.5–12–MHz sonogram (Performa, Acoustic Imaging) shows lesion to correspond to clustered microcysts. Follow-up was recommended instead of biopsy.

 


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Fig. 4D 57-year-old woman with palpable mass due to clustered microcysts that enlarged and then regressed on follow-up. Transverse L7.5–12–MHz sonogram at 5 months' follow-up shows slight enlargement in several anechoic spaces. Continued follow-up was recommended.

 


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Fig. 4E 57-year-old woman with palpable mass due to clustered microcysts that enlarged and then regressed on follow-up. Transverse L7–13–MHz sonogram with spatial compounding (Elegra, Siemens Medical Solutions) at 41 months' follow-up shows moderate decrease in overall size of lesion and regression of individual microcysts.

 


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Fig. 5A 48-year-old woman with clustered microcysts shown with improved technique. Antiradial L7–13–MHz sonogram without spatial compounding (Elegra, Siemens Medical Solutions) shows irregular hypoechoic mass initially considered suspicious with biopsy recommended.

 


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Fig. 5B 48-year-old woman with clustered microcysts shown with improved technique. Antiradial L7–13–MHz sonogram with spatial compounding and application of increased pressure while scanning shows lesion to be clustered microcysts. Lesion was followed and had decreased at 26 months' follow-up.

 


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Fig. 6A 75-year-old woman with invasive lobular carcinoma manifest as new indistinctly marginated mass mammographically. Radial L5–12–MHz sonogram (HDI 3500, Philips-ATL) shows hypoechoic lesion thought to possibly represent clustered microcysts.

 


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Fig. 6B 75-year-old woman with invasive lobular carcinoma manifest as new indistinctly marginated mass mammographically. Antiradial (B) and radial (C) L7–13–MHz sonograms with spatial compounding (Elegra, Siemens Medical Solutions) show hypoechoic mass with angular (arrow, C) and indistinct margins. Spatial compounding helps to better depict angular and indistinct margins, which facilitates classification of this as suspicious mass needing biopsy. Sonographically guided 14-gauge core biopsy showed invasive lobular carcinoma.

 


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Fig. 6C 75-year-old woman with invasive lobular carcinoma manifest as new indistinctly marginated mass mammographically. Antiradial (B) and radial (C) L7–13–MHz sonograms with spatial compounding (Elegra, Siemens Medical Solutions) show hypoechoic mass with angular (arrow, C) and indistinct margins. Spatial compounding helps to better depict angular and indistinct margins, which facilitates classification of this as suspicious mass needing biopsy. Sonographically guided 14-gauge core biopsy showed invasive lobular carcinoma.

 

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