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Rosai-Dorfman Disease of the Breast

Cynthia B. Pham1, Lynne V. Abruzzo1, Elise Cook1, Gary J. Whitman1 and Tanya W. Stephens1

1 Division of Diagnostic Imaging, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 57, Houston, TX 77030.



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Fig. 1A 53-year-old woman with Rosai-Dorfman disease of breast. Left breast craniocaudal mammogram shows 1.5-cm high-density mass with indistinct margins (arrow).

 


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Fig. 1B 53-year-old woman with Rosai-Dorfman disease of breast. Left breast longitudinal sonogram shows ill-defined, hypoechoic mass (arrow).

 


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Fig. 1C 53-year-old woman with Rosai-Dorfman disease of breast. Photomicrograph shows histiocytes with emperipolesis (arrowhead) in background of lymphocytes, plasma cells, and fibrosis. (H and E, x500)

 

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