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Radiologic-Pathologic Conference of The University of Ankara Medical School

Metaplastic Breast Carcinoma with Osteochondrosarcomatous Differentiation

¹ Department of Diagnostic Radiology, Breast Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX 77230.
² Department of Radiology, Ankara University Medical School, Ankara, Turkey.
³ Department of Pathology, Ankara University Medical School, Ankara, Turkey.
⁴ Department of Pathology, Clinical Cytology Section, Ankara University Medical School, Ankara, Turkey.
⁵ Department of Surgery, Ankara University Medical School, Ankara, Turkey.

View larger version (68K): [in a new window]   Fig. 1A —75-year-old woman with palpable abnormality in upper right breast. Mammograms revealed 4 x 2 cm circumscribed, virtually completely calcified ovoid mass at 10-o'clock position in right breast. Although mass was largely circumscribed, calcifications took irregular form at medial and lateral margins of mass (arrows). At 12-o'clock region, smaller mass lesion with irregular, microlobulated margins and associated architectural distortion is seen (thin arrow) in background of nodular breast tissue. Incisional biopsy of larger mass revealed metaplastic carcinoma with osteochondrosarcomatous differentiation.

View larger version (70K): [in a new window]   Fig. 1B —75-year-old woman with palpable abnormality in upper right breast. Mammograms revealed 4 x 2 cm circumscribed, virtually completely calcified ovoid mass at 10-o'clock position in right breast. Although mass was largely circumscribed, calcifications took irregular form at medial and lateral margins of mass (arrows). At 12-o'clock region, smaller mass lesion with irregular, microlobulated margins and associated architectural distortion is seen (thin arrow) in background of nodular breast tissue. Incisional biopsy of larger mass revealed metaplastic carcinoma with osteochondrosarcomatous differentiation.

View larger version (177K): [in a new window]   Fig. 1C —75-year-old woman with palpable abnormality in upper right breast. Mastectomy specimen showed multicentric metaplastic carcinoma with osteosarcomatous component and small area of ductal epithelial differentiation (arrowhead). Osteosarcomatous component of metaplastic tumor corresponded to densely calcified regions of tumor (arrow) shown on mammography, which represent bone formation. (H and E, x100)

View larger version (109K): [in a new window]   Fig. 1D —75-year-old woman with palpable abnormality in upper right breast. Six months later, patient presented with pulmonary complaints. CT of chest revealed left diffuse pleural thickening, pleural effusion, multiple bilateral calcified lung nodules (arrows), and parenchymal masses.

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