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Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?

Mukesh G. Harisinghani1, Mansi A. Saksena1, Peter F. Hahn1, Benjamin King1, John Kim1, Maha T. Torabi1 and Ralph Weissleder1

1 All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., White 270, Boston, MA 02114.



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  		Fig. 1A —Receiver operating characteristic curves. Graphs show recorded data of reviewer 1 (A) and reviewer 2 (B) for ferumoxtran-10-enhanced images only (dashed line) and combined unenhanced and ferumoxtran-10-enhanced images (solid line).

 


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  		Fig. 1B —Receiver operating characteristic curves. Graphs show recorded data of reviewer 1 (A) and reviewer 2 (B) for ferumoxtran-10-enhanced images only (dashed line) and combined unenhanced and ferumoxtran-10-enhanced images (solid line).

 


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  		Fig. 2A —Pathologically proven benign lymph node in 62-year-old man with prostate cancer. Unenhanced (A) and ferumoxtran-10-enhanced (B) T2*-weighted gradient-refocused echo images of pelvis show 8-mm lymph node (arrow) with prominent hilum. Less-experienced reviewer 1 required both unenhanced and contrast-enhanced images to make correct diagnosis, whereas more-experienced reviewer 2 was able to characterize node as benign on basis of contrast-enhanced image alone.

 


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  		Fig. 2B —Pathologically proven benign lymph node in 62-year-old man with prostate cancer. Unenhanced (A) and ferumoxtran-10-enhanced (B) T2*-weighted gradient-refocused echo images of pelvis show 8-mm lymph node (arrow) with prominent hilum. Less-experienced reviewer 1 required both unenhanced and contrast-enhanced images to make correct diagnosis, whereas more-experienced reviewer 2 was able to characterize node as benign on basis of contrast-enhanced image alone.

 

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