High Spectral and Spatial Resolution MRI of Breast Lesions: Preliminary Clinical Experience
Milica Medved1,
Gillian M. Newstead1,
Hiroyuki Abe1,
Marta A. Zamora1,
Olufunmilayo I. Olopade2 and
Gregory S. Karczmar1
1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave., MC
2026, Chicago, IL 60637.
2 Section of Hematology and Oncology, The University of Chicago, Chicago, IL
60637.
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Fig. 1 —Histogram shows sizes of lesions for 30 imaged patients.
Lesion size ranged from 7 to 58 mm, and average lesion size was 22 mm.
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Fig. 2A —Patient 1: 67-year-old woman with noncalcified fibrocystic
change with usual ductal hyperplasia nodule. Standard clinical postcontrast
T1-weighted fat-saturated image (A), high spectral and spatial
resolution (HiSS) image (B), and dynamic contrast-enhanced MR
subtraction image at second minute postinjection (C) in sagittal
projection are displayed.
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Fig. 2B —Patient 1: 67-year-old woman with noncalcified fibrocystic
change with usual ductal hyperplasia nodule. Standard clinical postcontrast
T1-weighted fat-saturated image (A), high spectral and spatial
resolution (HiSS) image (B), and dynamic contrast-enhanced MR
subtraction image at second minute postinjection (C) in sagittal
projection are displayed.
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Fig. 2C —Patient 1: 67-year-old woman with noncalcified fibrocystic
change with usual ductal hyperplasia nodule. Standard clinical postcontrast
T1-weighted fat-saturated image (A), high spectral and spatial
resolution (HiSS) image (B), and dynamic contrast-enhanced MR
subtraction image at second minute postinjection (C) in sagittal
projection are displayed.
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Fig. 3A —Patient 2: 41-year-old woman presenting with mammographically
detected grade II ductal carcinoma with ductal carcinoma in situ. Standard
clinical postcontrast T1-weighted fat-saturated image (A), high
spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 3B —Patient 2: 41-year-old woman presenting with mammographically
detected grade II ductal carcinoma with ductal carcinoma in situ. Standard
clinical postcontrast T1-weighted fat-saturated image (A), high
spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 3C —Patient 2: 41-year-old woman presenting with mammographically
detected grade II ductal carcinoma with ductal carcinoma in situ. Standard
clinical postcontrast T1-weighted fat-saturated image (A), high
spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 4A —Patient 3: 67-year-old woman with invasive lobular carcinoma.
Standard clinical postcontrast T1-weighted fat-saturated image (A),
high spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 4B —Patient 3: 67-year-old woman with invasive lobular carcinoma.
Standard clinical postcontrast T1-weighted fat-saturated image (A),
high spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 4C —Patient 3: 67-year-old woman with invasive lobular carcinoma.
Standard clinical postcontrast T1-weighted fat-saturated image (A),
high spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 5A —Patient 4: 66-year-old woman with infiltrating ductal
carcinoma mass lesion. Standard clinical postcontrast T1-weighted
fat-saturated image (A), high spectral and spatial resolution (HiSS)
image (B), and dynamic contrast-enhanced MR subtraction image at second
minute postinjection (C) in sagittal projection are displayed.
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Fig. 5B —Patient 4: 66-year-old woman with infiltrating ductal
carcinoma mass lesion. Standard clinical postcontrast T1-weighted
fat-saturated image (A), high spectral and spatial resolution (HiSS)
image (B), and dynamic contrast-enhanced MR subtraction image at second
minute postinjection (C) in sagittal projection are displayed.
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Fig. 5C —Patient 4: 66-year-old woman with infiltrating ductal
carcinoma mass lesion. Standard clinical postcontrast T1-weighted
fat-saturated image (A), high spectral and spatial resolution (HiSS)
image (B), and dynamic contrast-enhanced MR subtraction image at second
minute postinjection (C) in sagittal projection are displayed.
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Fig. 6A —Patient 5: 48-year-old woman with ductal carcinoma in situ.
Standard clinical postcontrast T1-weighted fat-saturated image (A),
high spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 6B —Patient 5: 48-year-old woman with ductal carcinoma in situ.
Standard clinical postcontrast T1-weighted fat-saturated image (A),
high spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 6C —Patient 5: 48-year-old woman with ductal carcinoma in situ.
Standard clinical postcontrast T1-weighted fat-saturated image (A),
high spectral and spatial resolution (HiSS) image (B), and dynamic
contrast-enhanced MR subtraction image at second minute postinjection
(C) in sagittal projection are displayed.
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Fig. 7A —Patient 6: 40-year-old woman at high risk for breast cancer
who presented with palpable invasive ductal carcinoma mass. All images are
shown in sagittal projection. Conventional postcontrast T1-weighted MR
image.
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Fig. 7B —Patient 6: 40-year-old woman at high risk for breast cancer
who presented with palpable invasive ductal carcinoma mass. All images are
shown in sagittal projection. Precontrast high spectral and spatial resolution
(HiSS) images of same slice as A displayed using different window
settings to show general breast anatomy (B) and to show inherent
contrast within lesion (C).
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Fig. 7C —Patient 6: 40-year-old woman at high risk for breast cancer
who presented with palpable invasive ductal carcinoma mass. All images are
shown in sagittal projection. Precontrast high spectral and spatial resolution
(HiSS) images of same slice as A displayed using different window
settings to show general breast anatomy (B) and to show inherent
contrast within lesion (C).
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Fig. 7D —Patient 6: 40-year-old woman at high risk for breast cancer
who presented with palpable invasive ductal carcinoma mass. All images are
shown in sagittal projection. Image shows difference between 3-min
postcontrast and precontrast HiSS images. Image reveals spatial inhomogeneity
of contrast agent effect on water resonance that was observed at 3 min after
injection and resulted in peak height decreases (dark) in some and
increases (bright) in other regions. Arrows point to 2 voxels for
which water resonance is shown in E and F.
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Fig. 7E —Patient 6: 40-year-old woman at high risk for breast cancer
who presented with palpable invasive ductal carcinoma mass. All images are
shown in sagittal projection. Images illustrate water resonance measured for 2
voxels indicated by arrows in D before (dashed line) and after
(solid line) administration of contrast material for comparison. In
the voxel depicted in E, there appears to be a single water resonance
that is slightly shifted and homogeneously broadened after contrast agent
administration. In the voxel depicted in F, two components can be
observed; one is broadened and shifted, and the other shows a small increase
in height after contrast agent administration. The changes observed are above
the noise level and can be used as a source of MR contrast. E and
F are shown on an arbitrary scale.
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Fig. 7F —Patient 6: 40-year-old woman at high risk for breast cancer
who presented with palpable invasive ductal carcinoma mass. All images are
shown in sagittal projection. Images illustrate water resonance measured for 2
voxels indicated by arrows in D before (dashed line) and after
(solid line) administration of contrast material for comparison. In
the voxel depicted in E, there appears to be a single water resonance
that is slightly shifted and homogeneously broadened after contrast agent
administration. In the voxel depicted in F, two components can be
observed; one is broadened and shifted, and the other shows a small increase
in height after contrast agent administration. The changes observed are above
the noise level and can be used as a source of MR contrast. E and
F are shown on an arbitrary scale.
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Copyright © 2006 by the American Roentgen Ray Society.
