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Drug-Induced Eosinophilic Pneumonia: High-Resolution CT Findings in 14 Patients

Carolina A. Souza1, Nestor L. Müller1, Takeshi Johkoh2 and Masanori Akira3

1 Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W 12th Ave., Vancouver V5Z 1M9, Canada.
2 Department of Radiology and Medical Physics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0825, Japan.
3 National Kinki Chuo Hospital for Chest Disease, Sakai City, Osaka, 591-8555, Japan.


Figure 1
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  		Fig. 1 —High-resolution CT scan of 49-year-old woman receiving sodium cromoglycate for asthma shows air-space consolidation in periphery of right upper lobe.

 

Figure 2
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  		Fig. 2 —High-resolution CT scan of 81-year-old man receiving 5-aminosalicylic acid for colitis shows extensive bilateral air-space consolidation and ground-glass opacity. Mild septal thickening is seen in anterior aspects of both lungs (arrows).

 

Figure 3
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  		Fig. 3A —31-year-old woman receiving minocycline for sinusitis. High-resolution CT scan shows patchy ground-glass opacity and mild consolidation in a peripheral distribution. Also seen are small centrilobular nodules (straight arrows) and nodular thickening of lobular septa and major fissure (curved arrows).

 

Figure 4
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  		Fig. 3B —31-year-old woman receiving minocycline for sinusitis. High-resolution CT scan at a lower level shows septal lines (arrows).

 

Figure 5
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  		Fig. 4A —50-year-old man receiving methotrexate therapy for non-Hodgkin's lymphoma. High-resolution CT scan shows area of ground-glass opacity and reticulation in periphery of left upper lobe. Also seen are a few small nodules (arrows).

 

Figure 6
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  		Fig. 4B —50-year-old man receiving methotrexate therapy for non-Hodgkin's lymphoma. High-resolution CT scan at a lower level shows patchy areas of consolidation and ground-glass opacity in a peripheral distribution.

 

Figure 7
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  		Fig. 5 —High-resolution CT scan of 47-year-old man receiving phenytoin for seizures shows patchy bilateral air-space consolidation in a peripheral distribution. Focal area of ground-glass opacity surrounded by crescent-shaped consolidation ("reverse halo" sign) is seen in left lung (arrow).

 

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