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MDCT Appearance of Gastrointestinal Stromal Tumors After Therapy with Imatinib Mesylate

¹ Both authors: Department of Radiology, The Churchill Hospital, Old Road, Oxford, OX3 7LJ, United Kingdom.

View larger version (88K): [in a new window]   Fig. 1A —82-year-old woman presenting with melena. Axial CT images show large lower esophageal tumor on staging study (A). Tumor shows cystic changes on follow-up study after chemotherapy (B).

View larger version (77K): [in a new window]   Fig. 1B —82-year-old woman presenting with melena. Axial CT images show large lower esophageal tumor on staging study (A). Tumor shows cystic changes on follow-up study after chemotherapy (B).

View larger version (88K): [in a new window]   Fig. 2A —83-year-old man presenting with weight loss and altered bowel habit. Axial CT image shows large mesenteric mass and partly cystic liver lesion.

View larger version (127K): [in a new window]   Fig. 2B —83-year-old man presenting with weight loss and altered bowel habit. Follow-up studies after chemotherapy show progressive reduction in size and extensive cystic changes in these lesions.

View larger version (119K): [in a new window]   Fig. 2C —83-year-old man presenting with weight loss and altered bowel habit. Follow-up studies after chemotherapy show progressive reduction in size and extensive cystic changes in these lesions.

View larger version (125K): [in a new window]   Fig. 2D —83-year-old man presenting with weight loss and altered bowel habit. Further follow-up study shows punctate calcification in mesenteric mass (arrows).

View larger version (93K): [in a new window]   Fig. 3A —85-year-old man presenting with chest wall mass. He had previously undergone gastrectomy for gastrointestinal stromal tumor. Images from staging CT study show lesion in right anterior chest wall (A, arrow) and lobulated mass in upper abdomen (B, arrow).

View larger version (104K): [in a new window]   Fig. 3B —85-year-old man presenting with chest wall mass. He had previously undergone gastrectomy for gastrointestinal stromal tumor. Images from staging CT study show lesion in right anterior chest wall (A, arrow) and lobulated mass in upper abdomen (B, arrow).

View larger version (85K): [in a new window]   Fig. 3C —85-year-old man presenting with chest wall mass. He had previously undergone gastrectomy for gastrointestinal stromal tumor. Follow-up studies after chemotherapy show resolution of chest wall mass (C) and progressive shrinkage of upper abdominal lesion, with extensive cystic changes (D and E).

View larger version (108K): [in a new window]   Fig. 3D —85-year-old man presenting with chest wall mass. He had previously undergone gastrectomy for gastrointestinal stromal tumor. Follow-up studies after chemotherapy show resolution of chest wall mass (C) and progressive shrinkage of upper abdominal lesion, with extensive cystic changes (D and E).

View larger version (99K): [in a new window]   Fig. 3E —85-year-old man presenting with chest wall mass. He had previously undergone gastrectomy for gastrointestinal stromal tumor. Follow-up studies after chemotherapy show resolution of chest wall mass (C) and progressive shrinkage of upper abdominal lesion, with extensive cystic changes (D and E).

View larger version (85K): [in a new window]   Fig. 4A —52-year-old woman presenting with right iliac fossa mass. She had previously undergone resection of small bowel because of gastrointestinal stromal tumor. Axial CT image shows large pelvic mass and mass in right anterior abdominal wall.

View larger version (91K): [in a new window]   Fig. 4B —52-year-old woman presenting with right iliac fossa mass. She had previously undergone resection of small bowel because of gastrointestinal stromal tumor. Follow-up studies after chemotherapy show progressive growth of these lesions (B and C) and new satellite nodule in anterior abdominal wall (C, arrow).

View larger version (93K): [in a new window]   Fig. 4C —52-year-old woman presenting with right iliac fossa mass. She had previously undergone resection of small bowel because of gastrointestinal stromal tumor. Follow-up studies after chemotherapy show progressive growth of these lesions (B and C) and new satellite nodule in anterior abdominal wall (C, arrow).

View larger version (96K): [in a new window]   Fig. 5A —61-year-old man presenting with neurofibromatosis, type I, and right iliac fossa mass. Staging CT study shows large mesenteric mass.

View larger version (88K): [in a new window]   Fig. 5B —61-year-old man presenting with neurofibromatosis, type I, and right iliac fossa mass. Repeated studies after patient's acute presentation show enlargement of mass (B). An air-fluid level is seen within mass, with loop of bowel closely apposed to it (C). These features are of malignant fistula.

View larger version (99K): [in a new window]   Fig. 5C —61-year-old man presenting with neurofibromatosis, type I, and right iliac fossa mass. Repeated studies after patient's acute presentation show enlargement of mass (B). An air-fluid level is seen within mass, with loop of bowel closely apposed to it (C). These features are of malignant fistula.

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