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Second-Generation Sonographic Contrast Agent for Differential Diagnosis of Perisplenic Lesions

Christian Görg1 and Tillmann Bert1

1 Both authors: Departments of Internal Medicine and Hematology, Philipps University Marburg, Baldingerstrasse, 35043 Marburg/Lahn, Germany.


Figure 1
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  		Fig. 1A —34-year-old man with incidentally found perisplenic tumor (case 1). On B-mode sonography, 7 x 3 cm hypoechoic tumor was seen beneath spleen.

 

Figure 2
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  		Fig. 1B —34-year-old man with incidentally found perisplenic tumor (case 1). Contrast-enhanced sonography shows isoechoic enhancement in comparison with spleen in late parenchymal phase (5 min), suggesting accessory spleen.

 

Figure 3
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  		Fig. 1C —34-year-old man with incidentally found perisplenic tumor (case 1). Contrast-enhanced CT confirmed diagnosis of accessory spleen.

 

Figure 4
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  		Fig. 2A —50-year-old woman with neuroendocrine tumor (case 8). On B-mode sonography, small round isoechoic tumor was seen beneath spleen.

 

Figure 5
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  		Fig. 2B —50-year-old woman with neuroendocrine tumor (case 8). Contrast-enhanced sonography shows isoechoic enhancement in comparison with spleen in late parenchymal phase (4 min), suggesting accessory spleen.

 

Figure 6
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  		Fig. 3A —78-year-old man with neuroendocrine tumor (case 7). On B-mode sonography, 3-cm round isoechoic tumor was seen beneath spleen.

 

Figure 7
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  		Fig. 3B —78-year-old man with neuroendocrine tumor (case 7). Contrast-enhanced sonography shows hypoechoic enhancement in comparison with spleen in parenchymal phase (2 min), which excluded accessory spleen. Somatostatin scintigraphy confirmed metastasis.

 

Figure 8
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  		Fig. 4A —46-year-old woman with incidentally found perisplenic tumor (case 11). On B-mode sonography, 5-cm round hypoechoic tumor was seen beneath spleen.

 

Figure 9
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  		Fig. 4B —46-year-old woman with incidentally found perisplenic tumor (case 11). Contrast-enhanced sonography shows complex enhancement in arterial phase (23 sec) with hyperechoic and hypoechoic enhancement in comparison with spleen in early parenchymal phase (56 sec), which excluded accessory spleen.

 

Figure 10
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  		Fig. 4C —46-year-old woman with incidentally found perisplenic tumor (case 11). Contrast-enhanced CT shows hypodense enhancement of tumor, which excluded an accessory spleen.

 

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