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Technical Feasibility and Biocompatibility of a Newly Designed Separating Stent-Graft in the Normal Canine Aorta

Young-Cheol Weon1, Sung-Gwon Kang2, Jin Wook Chung3, Young Il Kim3, Jae Hyung Park3 and Do Yun Lee4

1 Department of Radiology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
2 Department of Interventional Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumidong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea.
3 Department of Diagnostic Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
4 Department of Diagnostic Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.


Figure 1
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Fig. 1A —Components of separating stent-graft (34 mm x 10 cm). Outer graft-stent consists of three parts: proximal stent (A), graft made of synthetic ultrathin polyester textile fabric (B), and distal stent (C).

 

Figure 2
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Fig. 1B —Components of separating stent-graft (34 mm x 10 cm). Outer graft-stent consists of three parts: proximal stent (A), graft made of synthetic ultrathin polyester textile fabric (B), and distal stent (C).

 

Figure 3
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Fig. 1C —Components of separating stent-graft (34 mm x 10 cm). Outer graft-stent consists of three parts: proximal stent (A), graft made of synthetic ultrathin polyester textile fabric (B), and distal stent (C).

 

Figure 4
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Fig. 2 —Diagrams show components of separating stent-graft introducing system: 10-French synthetic resin sheath (A), synthetic resin pusher (B), coil pusher (C), guidewire-passing tube (D), olive tip (E), loader for inner bare stent (F), loader pusher (G), and pusher for inner bare stent (H). (Reprinted with permission from Kang et al. [16])

 

Figure 5
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Fig. 3A —Case from 12-week follow-up. Three angiograms obtained before (A), just after (B), and 12 weeks after stent-graft placement (C) in dog in 12-week follow-up group. Stent is intact without any deformity or migration in follow-up angiogram. Transparent neointima covers all stent-grafts. This neointima was very thin (< 1 mm) and regular on gross (D) and microscopic (E) examination.

 

Figure 6
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Fig. 3B —Case from 12-week follow-up. Three angiograms obtained before (A), just after (B), and 12 weeks after stent-graft placement (C) in dog in 12-week follow-up group. Stent is intact without any deformity or migration in follow-up angiogram. Transparent neointima covers all stent-grafts. This neointima was very thin (< 1 mm) and regular on gross (D) and microscopic (E) examination.

 

Figure 7
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Fig. 3C —Case from 12-week follow-up. Three angiograms obtained before (A), just after (B), and 12 weeks after stent-graft placement (C) in dog in 12-week follow-up group. Stent is intact without any deformity or migration in follow-up angiogram. Transparent neointima covers all stent-grafts. This neointima was very thin (< 1 mm) and regular on gross (D) and microscopic (E) examination.

 

Figure 8
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Fig. 3D —Case from 12-week follow-up. Three angiograms obtained before (A), just after (B), and 12 weeks after stent-graft placement (C) in dog in 12-week follow-up group. Stent is intact without any deformity or migration in follow-up angiogram. Transparent neointima covers all stent-grafts. This neointima was very thin (< 1 mm) and regular on gross (D) and microscopic (E) examination.

 

Figure 9
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Fig. 3E —Case from 12-week follow-up. Three angiograms obtained before (A), just after (B), and 12 weeks after stent-graft placement (C) in dog in 12-week follow-up group. Stent is intact without any deformity or migration in follow-up angiogram. Transparent neointima covers all stent-grafts. This neointima was very thin (< 1 mm) and regular on gross (D) and microscopic (E) examination.

 

Figure 10
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Fig. 4A —Case from 4-week follow-up group. Three angiograms obtained before (A), just after (B), and 4 weeks after stent-graft placement in dog in 4-week follow-up group (C). Focal narrowing was present at distal part of stent.

 

Figure 11
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Fig. 4B —Case from 4-week follow-up group. Three angiograms obtained before (A), just after (B), and 4 weeks after stent-graft placement in dog in 4-week follow-up group (C). Focal narrowing was present at distal part of stent.

 

Figure 12
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Fig. 4C —Case from 4-week follow-up group. Three angiograms obtained before (A), just after (B), and 4 weeks after stent-graft placement in dog in 4-week follow-up group (C). Focal narrowing was present at distal part of stent.

 

Figure 13
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Fig. 4D —Case from 4-week follow-up group. On gross examination, dark brown hematoma was present in this distal portion of stent-graft.

 

Figure 14
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Fig. 4E —Case from 4-week follow-up group. Microscopic examination at site of focal hematoma shows thin intimal cell layer, subintimal hematoma, and proliferation of smooth-muscle cells. In other portion, thin regular neointimal cell layer and smooth-muscle cell layer were observed.

 

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