AJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Doria, A. S.
Right arrow Articles by Babyn, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doria, A. S.
Right arrow Articles by Babyn, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Hotlight (NEW!)
Right arrow
What's Hotlight?

Dynamic Contrast-Enhanced MRI Quantification of Synovium Microcirculation in Experimental Arthritis

Andrea S. Doria1,2, Michael Noseworthy2,3,4, Wendy Oakden3, Rahim Moineddin5, Tammy Rayner1, Vivian Tassos1, Doreen Engelberts1, Kenneth Pritzker6, Marianne Rogers6, Roland Jong6 and Paul Babyn1,2

1 Department of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada.
2 Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
3 The Brain-Body Institute, St. Joseph's Healthcare, Hamilton, ON, Canada.
4 Departments of Radiology and Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada.
5 Department of Public Health, Family and Community Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
6 Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.


Figure 1
View larger version (107K):

[in a new window]
  		Fig. 1 —Sagittal dynamic contrast-enhanced MR images of albumin-injected knee showing unenhanced (A, F, K) and contrast-enhanced (B-D, G-I, L-N) images obtained on days 0 (before induction, A-D), 1 (after induction, F-I), and 28 (after induction, K-N) of arthritis. G, (day 1 of arthritis), Evidence of synovial inflammation with joint effusion and synovial enhancement (arrows) noted in suprapatellar (long arrow) and posterior recess (short arrow) of knee. Although level of synovial inflammation decreased in interval between days 1 and 28 of arthritis, persistent synovial reaction is identified (arrowheads, L) in chronic stage of arthritis. D, I, and N, Regions-of-interest used to delineate the perisynovial region to derive time-intensity curves for that joint on days 0 (E), 1 (J) and 28 (O) of arthritis. Note the increased signal slope seen in the acute stage of arthritis (day 1, J) as compared with the slopes obtained on days 0 (E) and 28 (O) of arthritis.

 

Figure 2
View larger version (15K):

[in a new window]
  		Fig. 2A —Linear regression scattergrams in albumin-injected knees. Scattergram shows correlation between serum levels of amyloid A and dynamic contrast-enhanced MRI-derived signal slope (dS/dt) (r = 0.62, p = 0.003).

 

Figure 3
View larger version (17K):

[in a new window]
  		Fig. 2B —Linear regression scattergrams in albumin-injected knees. Scattergram shows correlation between serum levels of amyloid A and dynamic contrast-enhanced MRI-derived capillary permeability (KPS{rho}) (r = 0.63, p = 0.002).

 

Figure 4
View larger version (20K):

[in a new window]
  		Fig. 3A —Areas under the curve of individual MRI parameters used for discrimination of inflammatory status of joint on days 1 (A) and 14 (B) of arthritis. Line graphs show differences in areas under the curve for five different MRI parameters in early arthritis (difference of areas under the curve between time-to-peak (TTP) and other parameters on day 1, p = 0.0002 (A) and between signal slope (dS/dt), capillary permeability (KPS{rho} and other parameters on day 14, p = 0.001, B). The areas under the curve of time-to-peak, maximal signal change ({Delta}S), signal slope, capillary permeability and leakage space volume (VE) were 0.875, 0.727, 0.656, 0.625, 0.586 on day 1 (A) and 0.667, 0.694, 0.944, 0.944 and 0.889 on day 14 (B), respectively. Dashed line = time-to-peak, crossed line = signal slope, thick solid line = capillary permeability, dotted line = maximal signal change, thin solid line = leakage space volume.

 

Figure 5
View larger version (18K):

[in a new window]
  		Fig. 3B —Areas under the curve of individual MRI parameters used for discrimination of inflammatory status of joint on days 1 (A) and 14 (B) of arthritis. Line graphs show differences in areas under the curve for five different MRI parameters in early arthritis (difference of areas under the curve between time-to-peak (TTP) and other parameters on day 1, p = 0.0002 (A) and between signal slope (dS/dt), capillary permeability (KPS{rho} and other parameters on day 14, p = 0.001, B). The areas under the curve of time-to-peak, maximal signal change ({Delta}S), signal slope, capillary permeability and leakage space volume (VE) were 0.875, 0.727, 0.656, 0.625, 0.586 on day 1 (A) and 0.667, 0.694, 0.944, 0.944 and 0.889 on day 14 (B), respectively. Dashed line = time-to-peak, crossed line = signal slope, thick solid line = capillary permeability, dotted line = maximal signal change, thin solid line = leakage space volume.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Roentgen Ray Society.