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Integrating Systems Biology and Medical Imaging: Understanding Disease Distribution in the Lung Model

Anthony J. Yun1, Patrick Y. Lee1 and Anthony N. Gerber2

1 Department of Radiology, Stanford University, 470 University Ave., Palo Alto, CA 94301.
2 Division of Pulmonary Medicine, University of California, San Francisco, San Francisco, CA.


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  		Fig. 1 —Systems biology model explains distribution of idiopathic pulmonary fibrosis (IPF) and sarcoidosis. Hypoxic pulmonary vasoconstriction (HPV) occurs predominantly at bases and in peripheral lung (A). Because pulmonary vasoconstriction is in part mediated by sympathetic nervous system and because sympathetic nervous system causes TH2 immune bias, we propose that distribution of pulmonary vasoconstriction will lead to relative areas of TH2 versus TH1 bias, as shown in diagram B. Radiographic distributions of IPF ({circ}), which exhibits TH2 features, and of sarcoidosis (X), which exhibits TH1 features, correlate with proposed regions of relative TH2 and TH1 bias (C). Th = TH = T helper.

 

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