Opposed-Phase MRI for Fat Quantification in Fat-Water Phantoms with 1H MR Spectroscopy to Resolve Ambiguity of Fat or Water Dominance
Jerry S. Chang1,
Bachir Taouli2,
Nouha Salibi3,
Elizabeth M. Hecht2,
Deanna G. Chin4 and
Vivian S. Lee2
1 Westwood Radiology Associates, Pascack Valley Hospital, Westwood, NY
07675.
2 Department of Radiology, NYU Medical Center, 560 First Ave., TCH-HW 202, New
York, NY 10016.
3 Siemens Medical Solutions, Malvern, PA 19355.
4 Department of Radiology, Robert Wood Johnson University Hospital, East
Brunswick, NJ 08816.

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Fig. 1A In-phase and opposed-phase imaging of fat-water phantoms.
Curve of signal intensity (SI) of fat-water phantoms on in-phase () and
opposed-phase ( ) images versus phantom fat fraction (FFP).
Arrow points to maximum SI loss on opposed-phased images for fat fraction of
50%.
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Fig. 1B In-phase and opposed-phase imaging of fat-water phantoms.
Corresponding in-phase and opposed-phase images and 1H MR
spectroscopy (MRS) images of three fat-water phantoms placed in water bath;
phantoms are composed of 30% (B), 50% (C), or 70% (D)
fat. Water peak (short arrow) is 4.7 ppm and fat peak (long
arrow) ranges from 1 to 1.5 ppm on MRS images. Example of placement of
regions of interest (circles, C) is shown in C. Maximum
signal loss on opposed-phase images is seen for phantom with 50% fat
(C). Phantoms with 30% (A) and 70% (B) fat are
indistinguishable on opposed-phase images. Without MRS to resolve for
fat-water dominance, high fat fraction may be misinterpreted as low fat
fraction.
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Fig. 1C In-phase and opposed-phase imaging of fat-water phantoms.
Corresponding in-phase and opposed-phase images and 1H MR
spectroscopy (MRS) images of three fat-water phantoms placed in water bath;
phantoms are composed of 30% (B), 50% (C), or 70% (D)
fat. Water peak (short arrow) is 4.7 ppm and fat peak (long
arrow) ranges from 1 to 1.5 ppm on MRS images. Example of placement of
regions of interest (circles, C) is shown in C. Maximum
signal loss on opposed-phase images is seen for phantom with 50% fat
(C). Phantoms with 30% (A) and 70% (B) fat are
indistinguishable on opposed-phase images. Without MRS to resolve for
fat-water dominance, high fat fraction may be misinterpreted as low fat
fraction.
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Fig. 1D In-phase and opposed-phase imaging of fat-water phantoms.
Corresponding in-phase and opposed-phase images and 1H MR
spectroscopy (MRS) images of three fat-water phantoms placed in water bath;
phantoms are composed of 30% (B), 50% (C), or 70% (D)
fat. Water peak (short arrow) is 4.7 ppm and fat peak (long
arrow) ranges from 1 to 1.5 ppm on MRS images. Example of placement of
regions of interest (circles, C) is shown in C. Maximum
signal loss on opposed-phase images is seen for phantom with 50% fat
(C). Phantoms with 30% (A) and 70% (B) fat are
indistinguishable on opposed-phase images. Without MRS to resolve for
fat-water dominance, high fat fraction may be misinterpreted as low fat
fraction.
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Fig. 2 Correlation between fat fraction calculated using
opposed-phase imaging (FFOPI) with 1H MR spectroscopy
for qualitative analysis to resolve ambiguity of fat or water dominance in
phantom with known fat fraction (FFP). y = 1.09x - 0.02,
R2 = 0.99, p < 0.001.
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Copyright © 2006 by the American Roentgen Ray Society.