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Meta-Analysis of Diagnostic and Screening Test Accuracy Evaluations: Methodologic Primer

Constantine Gatsonis1 and Prashni Paliwal1,2

1 Center for Statistical Sciences, Brown University, Box G-H, Providence RI, 02912.
2 Present address: Department of Psychiatry, Yale University, New Haven, CT 06511.


Figure 1
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  		Fig. 1 —Graph shows that averaging sensitivities and specificities can be misleading. TPR = true-positive rate, FPR = false-positive rate.

 

Figure 2
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  		Fig. 2 —Forest plot of CT sensitivity and specificity estimates and their confidence intervals. LAG = lymphangiography.

 

Figure 3
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  		Fig. 3 —Observed true-positive rates (TPR) and false-positive rates (FPR) for three imaging techniques. LAG = lymphangiography.

 

Figure 4
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  		Fig. 4 —Estimated SROC curves and original data points for three imaging techniques. TPR = true-positive rate, FPR = false-positive rate, LAG = lymphangiography.

 

Figure 5
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  		Fig. 5 —Summary Receiver Operating Characteristic curves with confidence intervals for selected (TPR, FPR) points. TPR = true-positive rate, FPR = false-positive rate, LAG = lymphangiography.

 

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