AJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Narisada, H.
Right arrow Articles by Korogi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Narisada, H.
Right arrow Articles by Korogi, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Hotlight (NEW!)
Right arrow
What's Hotlight?

Correlation Between Numeric Gadolinium-Enhanced Dynamic MRI Ratios and Prognostic Factors and Histologic Type of Breast Carcinoma

Hiroyuki Narisada1, Takatoshi Aoki1, Takakazu Sasaguri2, Hiroshi Hashimoto3, Tetsumi Konishi4, Masaru Morita5 and Yukunori Korogi1

1 Department of Radiology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu-shi, 807-8555 Japan.
2 Department of Pathology and Cell Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu-shi, Japan.
3 Department of Pathology and Oncology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu-shi, Japan.
4 First Department of Surgery, University of Occupational and Environmental Health, School of Medicine, Kitakyushu-shi, Japan.
5 Second Department of Surgery, University of Occupational and Environmental Health, School of Medicine, Kitakyushu-shi, Japan.


Figure 1
View larger version (21K):

[in a new window]
  		Fig. 1 —Scheme illustrates central and peripheral regions of interest (ROIs) in tumor. Center ROI measuring 8 mm2 is large square. Vertical and horizontal crosshairs form target at center of square. Four peripheral ROIs measuring 2 mm2 are small squares just within periphery of each tumor on each crosshair radial.

 

Figure 2
View larger version (146K):

[in a new window]
  		Fig. 2A —52-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. Unenhanced sagittal dynamic MR image.

 

Figure 3
View larger version (147K):

[in a new window]
  		Fig. 2B —52-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. MR image 1 minute after injection of contrast medium.

 

Figure 4
View larger version (142K):

[in a new window]
  		Fig. 2C —52-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. MR image 4 minutes after injection of contrast medium.

 

Figure 5
View larger version (183K):

[in a new window]
  		Fig. 2D —52-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. Photomicrograph of histologic specimen shows central large scarlike area composed of dense or loose collagen bundles (arrows), indicating fibrotic focus. Early peripheral/early central ratio, 1.26; delayed peripheral/delayed central, 1.08; delayed peripheral/early peripheral, 0.74; delayed central/early central, 0.86. (H and E, x3)

 

Figure 6
View larger version (15K):

[in a new window]
  		Fig. 3 —Scheme illustrates method of counting microvessels in peripheral and central regions of tumor. Microvessels were counted in five fields in each peripheral portion of each lesion (total, 20 peripheral fields). In central portion of each lesion, microvessels were counted in 10 fields.

 

Figure 7
View larger version (5K):

[in a new window]
  		Fig. 4 —Graph shows plots of early peripheral/early central values. Dots represent means, and lines through dots represent SD. Early peripheral/early central ratio for mucinous carcinoma was significantly higher than for invasive ductal carcinoma (IDC) (p < 0.0001) and ductal carcinoma in situ (DCIS) (p < 0.0001). Mucinous = mucinous carcinoma, IL = invasive lobular carcinoma. EP/EC = ratio of peripheral contrast enhancement ratio 1 minute after contrast administration to central contrast enhancement ratio 1 minute after contrast administration.

 

Figure 8
View larger version (5K):

[in a new window]
  		Fig. 5 —Graph shows plot of delayed central/early central values. Dots represent means, and lines through dots represent SD. Delayed central/early central ratio for mucinous carcinoma was significantly higher than for invasive ductal carcinoma (IDC) (p < 0.0001) and ductal carcinoma in situ (DCIS) (p < 0.0001). Delayed central/early central ratio for invasive lobular (IL) carcinoma was significantly higher than for invasive ductal carcinoma (p = 0.0005) and ductal carcinoma in situ (p = 0.0003). Mucinous = mucinous carcinoma, DC/EC = ratio of central contrast enhancement ratio 4 minutes after contrast administration to central contrast enhancement ratio 1 minute after contrast administration.

 

Figure 9
View larger version (130K):

[in a new window]
  		Fig. 6A —54-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 1. Unenhanced sagittal dynamic MR image.

 

Figure 10
View larger version (180K):

[in a new window]
  		Fig. 6B —54-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 1. MR image 1 minute after injection of contrast medium.

 

Figure 11
View larger version (166K):

[in a new window]
  		Fig. 6C —54-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 1. MR image 4 minutes after injection of contrast medium.

 

Figure 12
View larger version (210K):

[in a new window]
  		Fig. 6D —54-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 1. Photomicrograph of histologic specimen of tumor shows cellular growth pattern without fibrotic focus. Early peripheral/early central ratio, 0.72; delayed peripheral/delayed central, 0.74; delayed peripheral/early peripheral, 0.77; delayed central/early central, 0.75. (H and E, x3)

 

Figure 13
View larger version (173K):

[in a new window]
  		Fig. 7A —62-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. Unenhanced sagittal dynamic MR image.

 

Figure 14
View larger version (159K):

[in a new window]
  		Fig. 7B —62-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. MR image 1 minute after injection of contrast medium.

 

Figure 15
View larger version (143K):

[in a new window]
  		Fig. 7C —62-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. MR image 4 minutes after injection of contrast medium.

 

Figure 16
View larger version (167K):

[in a new window]
  		Fig. 7D —62-year-old woman with tumor classified as modified Scarff-Bloom-Richardson histologic grade 3. Photomicrograph of histologic specimen of tumor shows peripheral cellular growth (arrows) with central fibrotic focus (arrowheads). Early peripheral/early central ratio, 1.77; delayed peripheral/delayed central, 0.68; delayed peripheral/early peripheral, 0.79; delayed central/early central, 1.26. (H and E, x3)

 

Figure 17
View larger version (8K):

[in a new window]
  		Fig. 8 —Scatterplot of early peripheral/early central ratio versus ratio of peripheral to central microvessel density shows statistically significant correlation (r = 0.62, p < 0.0001). EP/EC = ratio of peripheral contrast enhancement ratio 1 minute after contrast administration to central contrast enhancement ratio 1 minute after contrast administration.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Roentgen Ray Society.