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Unusual Malignant Tumors of the Gallbladder

Min-Jeong Kim1, Kyoung Won Kim2, Hyo-Cheol Kim3, So Yeon Kim2, Seong Ho Park2, Ah Young Kim2, Hyun Kwon Ha2, Jae Ho Byun2, Hyung Jin Won2, Yong Moon Shin2, Pyo Nyun Kim2 and Moon-Gyu Lee2

1 Department of Radiology, Hallym University Sacred Heart Hospital, Anyang, Korea.
2 Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-2 dong, Songpa-ku, Seoul, Korea 138-736.
3 Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.


Figure 1
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Fig. 1A 71-year-old woman with papillary adenocarcinoma of gallbladder. Oblique coronal sonogram shows intraluminal polypoid echogenic masses (arrows) within distended gallbladder.

 

Figure 2
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Fig. 1B 71-year-old woman with papillary adenocarcinoma of gallbladder. Contrast-enhanced CT scan clearly depicts polypoid masses (arrows) with mild enhancement filling neck and body of gallbladder.

 

Figure 3
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Fig. 1C 71-year-old woman with papillary adenocarcinoma of gallbladder. Photograph of gross pathologic specimen shows intraluminal papillary growing mass in gallbladder.

 

Figure 4
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Fig. 2A 64-year-old woman with mucinous adenocarcinoma of gallbladder. Unenhanced CT scan reveals several punctate calcifications (arrows) and suspicious localized wall thickening in body of gallbladder.

 

Figure 5
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Fig. 2B 64-year-old woman with mucinous adenocarcinoma of gallbladder. On contrast-enhanced CT, mass is clearly visualized as localized wall thickening with enhancement and some multilocular lesion with rimlike enhancement (arrow). There also is direct invasion into segment IV of liver (arrowhead) and metastatic lymphadenopathy (curved arrow) along bilateral paraaortic area.

 

Figure 6
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Fig. 3A 43-year-old woman with signet ring cell carcinoma of gallbladder. Sonogram shows targetlike wall thickening (arrow) of fundus of gallbladder.

 

Figure 7
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Fig. 3B 43-year-old woman with signet ring cell carcinoma of gallbladder. CT scan reveals targetlike wall thickening with enhancement (arrow) of fundus of gallbladder. There also is noted massive necrotic lymphadenopathy (arrowheads) along porta hepatis, hepatoduodenal ligament, and porta cava space.

 

Figure 8
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Fig. 4A 51-year-old woman with adenosquamous cell carcinoma. On contrast-enhanced CT scan, huge heterogeneous enhancing mass replaces gallbladder fossa and directly invades adjacent liver. Mass is composed of endoluminal (arrow) and exophytic (E) mass with interrupted mucosal lining.

 

Figure 9
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Fig. 4B 51-year-old woman with adenosquamous cell carcinoma. On axial T2-weighted MR image (TR/TE, 4/134), endoluminal mass (arrow) shows low signal intensity, and exophytic mass (E) shows slightly high signal intensity.

 

Figure 10
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Fig. 4C 51-year-old woman with adenosquamous cell carcinoma. Axial T1-weighted image (TR/TE, 149/4) shows two components, which are endoluminal polypoid mass with high signal intensity (arrow) and huge exophytic mass with low signal intensity (E).

 

Figure 11
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Fig. 4D 51-year-old woman with adenosquamous cell carcinoma. On gadolinium-enhanced coronal MR image, huge mass with peripheral rim enhancement (arrows) replaces gallbladder fossa and invades adjacent liver.

 

Figure 12
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Fig. 5 64-year-old man with squamous cell carcinoma. Contrast-enhanced CT scan shows huge mass replacing gallbladder fossa (G) and direct invasion of adjacent liver (L). No lymphadenopathy is noted.

 

Figure 13
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Fig. 6A 77-year-old woman with sarcomatoid carcinoma. Sonogram shows heterogeneous echogenic mass (M) filling gallbladder.

 

Figure 14
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Fig. 6B 77-year-old woman with sarcomatoid carcinoma. Contrast-enhanced CT scan shows mild wall thickening of fundus and poorly enhanced endoluminal mass (M).

 

Figure 15
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Fig. 6C 77-year-old woman with sarcomatoid carcinoma. Photograph of gross pathologic specimen shows endoluminal mass in gallbladder with extensive necrosis (N) and peripheral viable tumor (arrow).

 

Figure 16
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Fig. 7A 48-year-old woman with small cell carcinoma of gallbladder. Contrast-enhanced CT scan shows heterogeneous enhancing mass (M) in gallbladder fossa and adjacent gallbladder wall thickening with enhancement (arrowhead). There are also noted multiple enlarged lymph nodes at porta hepatis and along common hepatic artery.

 

Figure 17
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Fig. 7B 48-year-old woman with small cell carcinoma of gallbladder. CT scans also reveal enlarged lymph nodes (L) and omental mass (O), respectively.

 

Figure 18
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Fig. 7C 48-year-old woman with small cell carcinoma of gallbladder. CT scans also reveal enlarged lymph nodes (L) and omental mass (O), respectively.

 

Figure 19
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Fig. 8A 70-year-old woman with malignant fibrous histiocytoma. Axial T2-weighted MR image (TR/TE, 4/134) shows huge mass (arrows) in gallbladder fossa with peripheral high signal intensity and central bright signal intensity.

 

Figure 20
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Fig. 8B 70-year-old woman with malignant fibrous histiocytoma. On gadolinium-enhanced axial MR image, huge mass with peripheral rim enhancement (arrows) replaces gallbladder fossa.

 

Figure 21
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Fig. 9A 45-year-old man with Burkitt's lymphoma. Contrast-enhanced CT scan shows small polypoid mass in gallbladder (arrow).

 

Figure 22
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Fig. 9B 45-year-old man with Burkitt's lymphoma. Photograph of gross pathologic specimen shows polypoid mass in gallbladder.

 

Figure 23
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Fig. 10 67-year-old woman with lymphoma of gallbladder. Contrast-enhanced CT scan shows markedly diffuse wall thickening of gallbladder with homogeneous low density (arrows).

 

Figure 24
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Fig. 11 53-year-old woman with metastatic melanoma of gallbladder. Contrast-enhanced CT scan shows intraluminal polypoid mass with wall enhancement (arrow) in gallbladder.

 

Figure 25
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Fig. 12 62-year-old man with metastatic hepatocellular carcinoma of gallbladder. Contrast-enhanced CT scan shows polypoid enhancing mass (arrow) with adjacent wall thickening of gallbladder. There is also noted hepatocellular carcinoma (arrowhead) containing iodized oil in liver.

 

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