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Anomalies of the Corpus Callosum: An MR Analysis of the Phenotypic Spectrum of Associated Malformations

Steven W. Hetts1, Elliott H. Sherr2, Stephanie Chao3, Sarah Gobuty2 and A. James Barkovich1

1 Department of Radiology, University of California at San Francisco, 505 Parnassus Ave., L358, San Francisco, CA 94143-0628.
2 Department of Neurology, University of California at San Francisco, San Francisco, CA.
3 University of California at San Francisco, School of Medicine, San Francisco, CA.


Figure 1
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Fig. 1A Midline sagittal MR images of normal cerebral commissures, callosal hypogenesis, and callosal agenesis. Sagittal T1-weighted image in 20-year-old woman shows normal cerebral commissures, including fully formed corpus callosum with rostrum (r), genu (g), body (b), and splenium (s). Anterior commissure is denoted by arrow, and hippocampal commissure is denoted by arrowhead.

 

Figure 2
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Fig. 1B Midline sagittal MR images of normal cerebral commissures, callosal hypogenesis, and callosal agenesis. Sagittal T1-weighted image in 12-year-old boy shows callosal hypogenesis, with genu and anterior body present, but posterior body, splenium, and rostrum absent.

 

Figure 3
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Fig. 1C Midline sagittal MR images of normal cerebral commissures, callosal hypogenesis, and callosal agenesis. Sagittal T1-weighted image in 10-year-old girl shows agenesis of corpus callosum, with concomitant medial hemispheric sulci oriented perpendicular to third ventricular roof.

 

Figure 4
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Fig. 2A Malformations of cortical development of varying extent and severity were found in patients with callosal hypogenesis or agenesis. Coronal T1-weighted image in 4-year-old boy shows periventricular nodular heterotopia (arrows) and dysplastic occipital cortex (arrowheads) in addition to dysplastic cerebellum.

 

Figure 5
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Fig. 2B Malformations of cortical development of varying extent and severity were found in patients with callosal hypogenesis or agenesis. Axial T2-weighted image in 17-year-old boy shows dysplastic frontal and cingulate cortex (black arrows) adjacent to interhemispheric cyst (white arrows).

 

Figure 6
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Fig. 2C Malformations of cortical development of varying extent and severity were found in patients with callosal hypogenesis or agenesis. Coronal T1-weighted image in 6-year-old girl shows lissencephaly with four-layer cortex.

 

Figure 7
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Fig. 3 Probst bundles. Coronal T1-weighted image in 14-year-old girl shows lateral callosal bundles of Probst (arrows) indenting superomedial margins of lateral ventricles.

 

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