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Comparison of Standard- and Low-Radiation-Dose CT for Quantification of Emphysema

David S. Gierada1, Thomas K. Pilgram1, Bruce R. Whiting1, Cheng Hong1,2, Andrew J. Bierhals1, Jin Hwan Kim1,3 and Kyongtae T. Bae1,2

1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd., St. Louis, MO 63110.
2 Present address: University of Pittsburgh Medical Center, Pittsburgh, PA 15213.
3 Present address: Radiology Department, Chungnam National University School of Medicine, Dae Jon, Korea 301-721.


Figure 1
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  		Fig. 1 —Graph shows emphysema index (percentage of lung volume with attenuation below given threshold) from scans obtained with low-dose technique (thin line) is slightly higher than that from scans obtained with standard-dose technique (thick line) (p < 0.05 for attenuation thresholds from -960 to -920 H, two-tailed paired Student's t tests).

 

Figure 2
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  		Fig. 2 —Scatterplot shows relation between low- and standard-dose emphysema indexes at threshold of -930 H. Total lung volume difference between low- and standard-dose CT scans was 3% or less in subjects indicated by circles and more than 3% in subjects indicated by triangles. By linear regression for all points, slope = 0.97, y-intercept = 3% (regression line); for circles only, slope = 0.96, y-intercept = 2%.

 

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