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Pulmonary Nodule Volumetric Measurement Variability as a Function of CT Slice Thickness and Nodule Morphology

Myria Petrou1, Leslie E. Quint1, Bin Nan2 and Laurence H. Baker3

1 Department of Radiology, University of Michigan, 1500 E Medical Center Dr., Ann Arbor, MI 48109.
2 Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI.
3 Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.


Figure 1
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  		Fig. 1A —Images show possible classifications of nodules based on shape: round or elongated. Round nodule in 63-year-old woman.

 

Figure 2
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  		Fig. 1B —Images show possible classifications of nodules based on shape: round or elongated. Elongated nodule in 57-year-old man.

 

Figure 3
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  		Fig. 2A —Images show possible classifications of nodules based on margins: smooth (including lobulated) or spiculated. Smooth nodule margins in 68-year-old man.

 

Figure 4
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  		Fig. 2B —Images show possible classifications of nodules based on margins: smooth (including lobulated) or spiculated. Spiculated nodule margins in 76-year-old man.

 

Figure 5
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  		Fig. 3A —Scatterplots show percent change in nodule volume measurements using different CT slice thicknesses. Percent change in nodule volume measurement between 2.5- and 1.25-mm-thick (A), 5- and 2.5-mm-thick (B), 5- and 1.25-mm-thick (C) CT sections plotted against nodule diameter.

 

Figure 6
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  		Fig. 3B —Scatterplots show percent change in nodule volume measurements using different CT slice thicknesses. Percent change in nodule volume measurement between 2.5- and 1.25-mm-thick (A), 5- and 2.5-mm-thick (B), 5- and 1.25-mm-thick (C) CT sections plotted against nodule diameter.

 

Figure 7
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  		Fig. 3C —Scatterplots show percent change in nodule volume measurements using different CT slice thicknesses. Percent change in nodule volume measurement between 2.5- and 1.25-mm-thick (A), 5- and 2.5-mm-thick (B), 5- and 1.25-mm-thick (C) CT sections plotted against nodule diameter.

 

Figure 8
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  		Fig. 4A —Bar graphs show change in volume measurement using different CT slice thicknesses: < 10% (black bars), 10-20% (white bars), > 20% (gray bars). Absolute percent change in volume measurements among nodules of different diameters when comparing values obtained with 2.5- and 1.25-mm-thick (A), 5- and 2.5-mm-thick (B), and 5- and 1.25-mm-thick (C) CT sections.

 

Figure 9
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  		Fig. 4B —Bar graphs show change in volume measurement using different CT slice thicknesses: < 10% (black bars), 10-20% (white bars), > 20% (gray bars). Absolute percent change in volume measurements among nodules of different diameters when comparing values obtained with 2.5- and 1.25-mm-thick (A), 5- and 2.5-mm-thick (B), and 5- and 1.25-mm-thick (C) CT sections.

 

Figure 10
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  		Fig. 4C —Bar graphs show change in volume measurement using different CT slice thicknesses: < 10% (black bars), 10-20% (white bars), > 20% (gray bars). Absolute percent change in volume measurements among nodules of different diameters when comparing values obtained with 2.5- and 1.25-mm-thick (A), 5- and 2.5-mm-thick (B), and 5- and 1.25-mm-thick (C) CT sections.

 

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