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Inhalational Talc Pneumoconiosis: Radiographic and CT Findings in 14 Patients

¹ Department of Radiology, Kinki-Chuo Chest Medical Center, 1180 Nagasone-cho, Sakai City, Osaka 591-8555, Japan.
² Department of Pathology, Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan.
³ Department of Internal Medicine, Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan.
⁴ Department of Environmental Health, National Institute of Industrial Health, Kawasaki 214-8585, Japan.

View larger version (135K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —61-year-old man with inhalational talc pneumoconiosis employed in talc industry for 20 years. Initial chest radiograph shows fine nodular opacities diffusely distributed throughout both lungs.

View larger version (154K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —61-year-old man with inhalational talc pneumoconiosis employed in talc industry for 20 years. Chest radiograph obtained at 15-year follow-up examination shows fine nodules and large opacity in upper zone of right lung and middle zone of left lung.

View larger version (120K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —61-year-old man with inhalational talc pneumoconiosis employed in talc industry for 20 years. Axial supine thin-section CT scan shows well-defined (arrowheads) and ill-defined (arrows) small nodular opacities mainly distributed in centrilobular location.

View larger version (90K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —61-year-old man with inhalational talc pneumoconiosis employed in talc industry for 20 years. Axial supine thin-section CT scan obtained at mediastinal settings shows large opacity and lymph nodes containing high-attenuation material.

View larger version (154K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2A —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. Chest radiograph shows small nodular opacities and large opacity.

View larger version (151K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2B —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. Chest radiograph obtained at 13-year follow-up examination shows large opacities associated with bilateral superior retraction of hila.

View larger version (117K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2C —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. Axial supine thin-section CT scan shows bandlike opacity parallel to pleural surface.

View larger version (91K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2D —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. In vitro low-kilovoltage radiograph of inflated and fixed lung. Crescent-shaped large opacity and small nodular opacities are evident.

View larger version (89K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2E —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. In vitro thin-section CT scan of inflated and fixed lung. Crescent-shaped large opacity is attached to pleural surface. Subpleural line (arrows) is evident.

View larger version (139K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2F —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. Photograph of histologic section through crescentic large opacity shows diffuse fibrosis and proliferation of dust-laden macrophages and multinucleated giant cells (arrows). (H and E, x4)

View larger version (125K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2G —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. Photomicrograph of biopsy specimen examined under polarized light shows fibrosis contains large accumulations of strongly birefringent dust particles.

View larger version (110K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2H —57-year-old man with inhalational talc pneumoconiosis employed in talc industry for 14 years. Histologic section from area of subpleural line shows peribronchiolar fibrosis joined by collapse and fibrosis of alveoli along thickened pleura (arrows). (H and E, x1.6)

View larger version (123K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3 —66-year-old man with inhalational talc pneumoconiosis. Axial supine thin-section CT scan shows subpleural line.

View larger version (135K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 4 —77-year-old man with inhalational talc pneumoconiosis. Histopathologic photograph shows nodular fibrosis (arrows) adjacent to vessels or bronchi. (H and E, x1.25)

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