HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tang, Y. M. Articles by Gill, D. Search for Related Content PubMed PubMed Citation Articles by Tang, Y. M. Articles by Gill, D. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

MRI Features of Bone Marrow Necrosis

¹ Department of Radiology, Princess Alexandra Hospital, Ipswich Rd., Woolloongabba, Brisbane, Queensland 4102, Australia.
² South Coast Radiology, Gold Coast, Queensland, Australia.
³ Department of Haematology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

View larger version (169K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —80-year-old man with bone marrow necrosis and relapse of lymphoma. History included diagnosis of diffuse large B-cell lymphoma diagnosed and managed with chemotherapy 7 years earlier. Early anterior epidural extraosseous extension of disease (not shown) was present at L5. MR images show extensive geographic pattern of signal abnormality of vertebral bodies. At follow-up MRI (not shown) 2 weeks after imaging, geographic abnormalities were stable, and epidural abnormalities had progressed, suggesting dual pathologic conditions. Photomicrograph of bone marrow trephine biopsy specimen shows extensive necrosis of hemopoietic and stromal elements (arrowhead) with loss of normal fat spaces and preservation of bone trabeculae (arrow). (H and E, x100)

View larger version (79K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —80-year-old man with bone marrow necrosis and relapse of lymphoma. History included diagnosis of diffuse large B-cell lymphoma diagnosed and managed with chemotherapy 7 years earlier. Early anterior epidural extraosseous extension of disease (not shown) was present at L5. MR images show extensive geographic pattern of signal abnormality of vertebral bodies. At follow-up MRI (not shown) 2 weeks after imaging, geographic abnormalities were stable, and epidural abnormalities had progressed, suggesting dual pathologic conditions. Sagittal T2-weighted MR image shows central areas of irregular patchy areas of low signal intensity (arrows). Margins of several lesions show irregular serpiginous rim of high signal intensity (arrowheads).

View larger version (77K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —80-year-old man with bone marrow necrosis and relapse of lymphoma. History included diagnosis of diffuse large B-cell lymphoma diagnosed and managed with chemotherapy 7 years earlier. Early anterior epidural extraosseous extension of disease (not shown) was present at L5. MR images show extensive geographic pattern of signal abnormality of vertebral bodies. At follow-up MRI (not shown) 2 weeks after imaging, geographic abnormalities were stable, and epidural abnormalities had progressed, suggesting dual pathologic conditions. Sagittal T1-weighted MR image shows central areas of irregular patchy areas of low signal intensity (arrows).

View larger version (76K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —80-year-old man with bone marrow necrosis and relapse of lymphoma. History included diagnosis of diffuse large B-cell lymphoma diagnosed and managed with chemotherapy 7 years earlier. Early anterior epidural extraosseous extension of disease (not shown) was present at L5. MR images show extensive geographic pattern of signal abnormality of vertebral bodies. At follow-up MRI (not shown) 2 weeks after imaging, geographic abnormalities were stable, and epidural abnormalities had progressed, suggesting dual pathologic conditions. Sagittal T1-weighted gadolinium-enhanced MR image shows central areas of irregular patchy areas of low signal intensity (arrows). Margins of several lesions show irregular serpiginous rim (arrowheads).

View larger version (72K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2A —65-year-old woman with bone marrow necrosis after chemotherapy for diffuse large B-cell lymphoma. Images show extensive signal abnormality involving entire spine. Imaging appearance is atypical of lymphomatous involvement and similar to that of bone infarcts seen at other sites. Sagittal T2-weighted MR image shows geographic areas of low intensity in posterior aspect of vertebral bodies (arrows) surrounded by peripheral rim of hyperintensity and external rim of low signal intensity (arrowheads).

View larger version (71K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2B —65-year-old woman with bone marrow necrosis after chemotherapy for diffuse large B-cell lymphoma. Images show extensive signal abnormality involving entire spine. Imaging appearance is atypical of lymphomatous involvement and similar to that of bone infarcts seen at other sites. Sagittal T1-weighted MR image shows geographic areas low signal intensity in posterior aspect of vertebral bodies (arrows).

View larger version (78K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2C —65-year-old woman with bone marrow necrosis after chemotherapy for diffuse large B-cell lymphoma. Images show extensive signal abnormality involving entire spine. Imaging appearance is atypical of lymphomatous involvement and similar to that of bone infarcts seen at other sites. Sagittal STIR MR image shows geographic areas of low signal intensity in posterior aspect of vertebral bodies (arrows) surrounded by peripheral rim of hyperintensity and further external rim of low signal intensity (arrowheads).

View larger version (117K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2D —65-year-old woman with bone marrow necrosis after chemotherapy for diffuse large B-cell lymphoma. Images show extensive signal abnormality involving entire spine. Imaging appearance is atypical of lymphomatous involvement and similar to that of bone infarcts seen at other sites. Photomicrograph of bone marrow trephine biopsy specimen shows extensive necrosis of bone marrow stromal and hemopoietic elements with loss of normal fat spaces (arrow) and preservation of bony trabeculae. Arrowhead indicates region of preserved fat spaces. (H and E, x20)

View larger version (72K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3A —19-year-old woman with bone marrow necrosis after chemotherapy for central nervous system lymphoproliferative disorder after renal transplantation. Extensive signal abnormality involved vertebral bodies. Sagittal T2-weighted MR image shows geographic central areas of high signal intensity (arrows) surrounded by well-defined rim of low signal intensity (arrowheads).

View larger version (81K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3B —19-year-old woman with bone marrow necrosis after chemotherapy for central nervous system lymphoproliferative disorder after renal transplantation. Extensive signal abnormality involved vertebral bodies. Sagittal T1-weighted MR image shows geographic central areas of high signal intensity (arrows) surrounded by well-defined rim of low signal intensity (arrowheads).

View larger version (103K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3C —19-year-old woman with bone marrow necrosis after chemotherapy for central nervous system lymphoproliferative disorder after renal transplantation. Extensive signal abnormality involved vertebral bodies. Sagittal T1-weighted fat-suppressed gadolinium-enhanced MR image shows geographic central areas of low signal intensity (arrows) surrounded by intensely enhanced rim (arrowheads).

View larger version (94K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3D —19-year-old woman with bone marrow necrosis after chemotherapy for central nervous system lymphoproliferative disorder after renal transplantation. Extensive signal abnormality involved vertebral bodies. Photomicrograph of bone marrow trephine biopsy specimen shows hypocellular bone marrow (treatment related) with preservation of fat spaces (black arrow) and area of necrosis of hematopoietic and stromal elements (arrowhead). Preservation of bone trabeculae (red arrow) is evident. (H and E, x100)

View larger version (144K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3E —19-year-old woman with bone marrow necrosis after chemotherapy for central nervous system lymphoproliferative disorder after renal transplantation. Extensive signal abnormality involved vertebral bodies. Coronal T1-weighted MR image obtained because of right hip and buttock pain shows extensive signal abnormalities in spine in A-C also present in pelvis (arrowheads) and proximal aspect of femur (arrow). Small effusion in right hip joint (not shown) with surrounding muscle edema was also present.

View larger version (136K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3F —19-year-old woman with bone marrow necrosis after chemotherapy for central nervous system lymphoproliferative disorder after renal transplantation. Extensive signal abnormality involved vertebral bodies. Coronal T2-weighted fat-suppressed MR image corresponding to E shows abnormalities in pelvis (arrowheads) and proximal aspects of femur (arrow).

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati