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Multistation Whole-Body High-Spatial-Resolution MR Angiography Using a 32-Channel MR System

Kambiz Nael1, Stefan G. Ruehm1, Henrik J. Michaely2, Roya Saleh1, Margaret Lee1, Gerhard Laub3 and J. Paul Finn1

1 Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, 10945 Le Conte Ave., Ste. 3371, Los Angeles, CA 90095-7206.
2 Department of Radiology, University Hospitals Grosshadem, Ludwig-Maximilians-University Munich, Munich, Germany.
3 Siemens Medical Solutions, Malvern, PA.


Figure 1
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Fig. 1 —Drawing shows coil positioning for whole-body contrast-enhanced MR angiography. By activating up to 76 coil elements over the body, no coil repositioning is required. (Courtesy of Siemens Medical Solutions)

 

Figure 2
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Fig. 2 —Four sequential stations with 500-mm field of view (FOV) and 50-mm overlap for whole-body MR angiography of 63-year-old man with severe right lower extremity claudication.

 

Figure 3
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Fig. 3 —Schematic shows MR angiography (MRA) and contrast injection protocol. Phase-encoding order was linear for stations I (HN) and II (CA) and centric for stations III (T) and IV (C). Preinjection "mask" measurement was acquired at each station immediately before respective contrast infusion and MRA. Drawings of syringes mark first and second contrast injections. Subjects were instructed to hold their breath during acquisitions of stations I (HN) and II (CA). HN = head-neck, CA = chest-abdomen, T = thighs, C = calves.

 

Figure 4
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Fig. 4A —Graphs show overall image quality scores. SMA = superior mesenteric artery, IMA = inferior mesenteric artery. Overall image quality scores for all arterial segments (A) and for arterial segments with > 10% narrowing (B). Data are mean ± SD, with SDs being shown by horizontal tic marks with each bar. Scoring scale was as follows: 1 = poor image quality and blurring of arterial segment; 2 = fair image quality, inadequate for confident diagnosis; 3 = good image quality and arterial enhancement, adequate for confident diagnosis; and 4 = excellent image quality and arterial enhancement, for highly confident diagnosis. Note that majority of arterial segments (82%) scored for image quality were relatively healthy (no stenosis or < 10% irregularities).

 

Figure 5
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Fig. 4B —Graphs show overall image quality scores. SMA = superior mesenteric artery, IMA = inferior mesenteric artery. Overall image quality scores for all arterial segments (A) and for arterial segments with > 10% narrowing (B). Data are mean ± SD, with SDs being shown by horizontal tic marks with each bar. Scoring scale was as follows: 1 = poor image quality and blurring of arterial segment; 2 = fair image quality, inadequate for confident diagnosis; 3 = good image quality and arterial enhancement, adequate for confident diagnosis; and 4 = excellent image quality and arterial enhancement, for highly confident diagnosis. Note that majority of arterial segments (82%) scored for image quality were relatively healthy (no stenosis or < 10% irregularities).

 

Figure 6
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Fig. 5 —Coronal maximum-intensity-projection image from whole-body contrast-enhanced MR angiography (thigh station) of 58-year-old woman with diabetes and peripheral vascular disease shows significant venous contamination affecting diagnostic image quality.

 

Figure 7
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Fig. 6A —63-year-old man with severe right lower extremity claudication. Coronal maximum-intensity-projection (MIP) image from whole-body contrast-enhanced MR angiography (CEMRA) depicts entire arterial tree with good image quality. Note absence of venous contamination. There is mild irregularity along course of abdominal aorta and severe stenosis of right common iliac artery (arrow).

 

Figure 8
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Fig. 6B —63-year-old man with severe right lower extremity claudication. Coronal MIP image from whole-body CE-MRA (B) and conventional angiogram (C) reveal mild irregularities of left common iliac artery with ulcerative plaque (black arrows). Thread line (white arrows) indicating minimal contrast flow through stenotic segments on both CE-MRA and conventional angiogram is noted.

 

Figure 9
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Fig. 6C —63-year-old man with severe right lower extremity claudication. Coronal MIP image from whole-body CE-MRA (B) and conventional angiogram (C) reveal mild irregularities of left common iliac artery with ulcerative plaque (black arrows). Thread line (white arrows) indicating minimal contrast flow through stenotic segments on both CE-MRA and conventional angiogram is noted.

 

Figure 10
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Fig. 7A —67-year-old woman with lower extremity claudication, hypertension, and history of transient ischemic attack. Coronal maximum-intensity-projection (MIP) from whole-body contrast-enhanced MR angiography (A) shows significant stenosis of innominate artery (arrow) and left common carotid artery, which is confirmed by catheter angiography (B).

 

Figure 11
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Fig. 7B —67-year-old woman with lower extremity claudication, hypertension, and history of transient ischemic attack. Coronal maximum-intensity-projection (MIP) from whole-body contrast-enhanced MR angiography (A) shows significant stenosis of innominate artery (arrow) and left common carotid artery, which is confirmed by catheter angiography (B).

 

Figure 12
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Fig. 7C —67-year-old woman with lower extremity claudication, hypertension, and history of transient ischemic attack. Magnified coronal MIP image from abdominal station (C) shows significant stenosis at origin of renal arteries (arrows) as well as distal narrowing of abdominal aorta with significant stenosis just before common iliac bifurcation (arrowhead). These findings were confirmed by catheter angiography (D and E). Coronal MIP images of stations III and IV (A) show patent runoff vasculatures, with no significant arterial disease.

 

Figure 13
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Fig. 7D —67-year-old woman with lower extremity claudication, hypertension, and history of transient ischemic attack. Magnified coronal MIP image from abdominal station (C) shows significant stenosis at origin of renal arteries (arrows) as well as distal narrowing of abdominal aorta with significant stenosis just before common iliac bifurcation (arrowhead). These findings were confirmed by catheter angiography (D and E). Coronal MIP images of stations III and IV (A) show patent runoff vasculatures, with no significant arterial disease.

 

Figure 14
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Fig. 7E —67-year-old woman with lower extremity claudication, hypertension, and history of transient ischemic attack. Magnified coronal MIP image from abdominal station (C) shows significant stenosis at origin of renal arteries (arrows) as well as distal narrowing of abdominal aorta with significant stenosis just before common iliac bifurcation (arrowhead). These findings were confirmed by catheter angiography (D and E). Coronal MIP images of stations III and IV (A) show patent runoff vasculatures, with no significant arterial disease.

 

Figure 15
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Fig. 8A —70-year-old man with bilateral lower extremity claudication and nonhealing ulcers of feet. Coronal maximum-intensity-projection (MIP) from whole-body contrast-enhanced MR angiography (A) shows irregularities along course of abdominal aorta and mild stenoses of right and left common iliac arteries (arrows), which were confirmed by catheter angiography (B). Coronal MIP image from station III (thigh) (A) shows proximal occlusion of right superficial femoral artery, with reperfusion of distal part by collaterals, and severe stenosis of left superficial femoral artery (arrow). Coronal MIP image from station IV (calf) (A) shows proximal occlusion of popliteal artery and anterior tibial artery at right, and severe stenosis of tibioperoneal trunk (arrow) and occlusion of anterior tibial artery at left (arrow).

 

Figure 16
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Fig. 8B —70-year-old man with bilateral lower extremity claudication and nonhealing ulcers of feet. Coronal maximum-intensity-projection (MIP) from whole-body contrast-enhanced MR angiography (A) shows irregularities along course of abdominal aorta and mild stenoses of right and left common iliac arteries (arrows), which were confirmed by catheter angiography (B). Coronal MIP image from station III (thigh) (A) shows proximal occlusion of right superficial femoral artery, with reperfusion of distal part by collaterals, and severe stenosis of left superficial femoral artery (arrow). Coronal MIP image from station IV (calf) (A) shows proximal occlusion of popliteal artery and anterior tibial artery at right, and severe stenosis of tibioperoneal trunk (arrow) and occlusion of anterior tibial artery at left (arrow).

 

Figure 17
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Fig. 8C —70-year-old man with bilateral lower extremity claudication and nonhealing ulcers of feet. Findings in left lower extremity are confirmed by catheter angiography.

 

Figure 18
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Fig. 8D —70-year-old man with bilateral lower extremity claudication and nonhealing ulcers of feet. Findings in left lower extremity are confirmed by catheter angiography.

 

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