Diagnostic Accuracy of Rim and Segmental MRI Enhancement of Colorectal Hepatic Metastasis After Administration of Mangafodipir Trisodium
Dow-Mu Koh1,
Gina Brown1,
Ziad Meer2,
Andrew R. Norman3 and
Janet E. Husband1
1 Academic Department of Radiology, Royal Marsden Hospital, Downs Rd., Sutton,
Surrey, United Kingdom SM2 5PT.
2 Department of Radiology, Hillingdon Hospital, Pield Health Rd., Middlesex,
United Kingdom UB8 3NN.
3 Department of Medical Statistics, Royal Marsden Hospital, Downs Rd., Sutton,
Surrey, United Kingdom SM3 6AL.
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Fig. 1A —Images from early phase of mangafodipir trisodium-enhanced
T1-weighted MRI show border characteristics of lesions. Insets are diagrams of
findings. Smooth border characterized by smooth contour without considerable
irregularity or protrusions.
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Fig. 1B —Images from early phase of mangafodipir trisodium-enhanced
T1-weighted MRI show border characteristics of lesions. Insets are diagrams of
findings. Blurred border characterized by ill-defined outline of lesion.
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Fig. 1C —Images from early phase of mangafodipir trisodium-enhanced
T1-weighted MRI show border characteristics of lesions. Insets are diagrams of
findings. Irregular border characterized by jagged contour.
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Fig. 1D —Images from early phase of mangafodipir trisodium-enhanced
T1-weighted MRI show border characteristics of lesions. Insets are diagrams of
findings. Irregular border with satellitism recorded for lesion with irregular
outline associated with smaller nodules in periphery.
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Fig. 3B —63-year-old man with rim-enhancing hepatic metastasis. T1-weighted
MR image (TR/TE, 128/4.6) obtained 30 minutes after administration of
mangafodipir trisodium shows lesion with irregular border and faint rim
enhancement.
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Fig. 3C —63-year-old man with rim-enhancing hepatic metastasis. T1-weighted
MR image obtained 24 hours after administration of mangafodipir trisodium and
after washout of contrast agent from hepatic parenchyma shows rim enhancement
better than does B.
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Fig. 4A —48-year-old woman with small rim-enhancing hepatic metastasis. Axial
T1-weighted images 30 minutes (A) and 24 hours (B) after
administration of mangafodipir trisodium contrast medium. Rim enhancement
highlights presence of small (2 mm) metastatic lesions (arrows)
within right lobe of liver. Patient refused surgery.
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Fig. 4B —48-year-old woman with small rim-enhancing hepatic metastasis. Axial
T1-weighted images 30 minutes (A) and 24 hours (B) after
administration of mangafodipir trisodium contrast medium. Rim enhancement
highlights presence of small (2 mm) metastatic lesions (arrows)
within right lobe of liver. Patient refused surgery.
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Fig. 5A —58-year-old man with segmental enhancement pattern of hepatic
metastasis. T1-weighted MR image obtained 30 minutes after mangafodipir
trisodium administration shows irregular metastatic lesion in left lobe of
liver.
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Fig. 5B —58-year-old man with segmental enhancement pattern of hepatic
metastasis. T1-weighted MR image obtained 24 hours after mangafodipir
trisodium administration shows normal clearance of contrast agent from right
lobe of liver, but persistent segmental hyperintensity (arrowheads)
is present within segment II of left lobe. Rim enhancement in this case is not
discernible because of presence of segmental enhancement.
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Fig. 6A —50-year-old man with segmental enhancement caused by small
metastatic lesion. Preoperative contrast-enhanced axial CT image obtained in
portal venous phase shows no evidence of disease in superior portion of right
lobe of liver.
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Fig. 6B —50-year-old man with segmental enhancement caused by small
metastatic lesion. T1-weighted axial MR images obtained 30 minutes (B)
and 24 hours (C) after contrast administration show segmental
enhancement on delayed scan. Small (2-mm) metastatic lesion at apex of
segmental enhancement (arrow, C) was confirmed at
histopathologic examination.
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Fig. 6C —50-year-old man with segmental enhancement caused by small
metastatic lesion. T1-weighted axial MR images obtained 30 minutes (B)
and 24 hours (C) after contrast administration show segmental
enhancement on delayed scan. Small (2-mm) metastatic lesion at apex of
segmental enhancement (arrow, C) was confirmed at
histopathologic examination.
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Copyright © 2007 by the American Roentgen Ray Society.
